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Effect of Recombinant Porcine Somatotropin on Lactational Performance and Metabolite Patterns in Sows and Growth of Nursing Pigs^1,2,3,

Cornell University, Ithaca, NY 14853-4801

Abstract

Sixteen crossbred sows (Yorkshire x Duroc) were used to determine the effect of recombinantly derived porcine somatotropin (pST) on lactational performance and the pattern of plasma metabolites and growth rate of nursing pigs. Daily s.c. injections of either pST (8.22 mg·sow^–1·^–1) or excipient were administered at 1000 on d 12 through d 29 of lactation. Jugular cannulas were inserted in three sows/treatment and hourly blood samples were collected on d 11 to 13 and d 28 to 29 of lactation to determine the effect of treatment on plasma concentrations of somatotropin, glucose and nonesterified fatty acids in plasma. Milk production and weight of nursing pigs were determined pretreatment (d 9 and 10) and on d 16, 22 and 28. Milk production of sows receiving pST progressively increased above that of control sows and was 22% greater on d 28. Milk composition was not affected by treatment with pST (P > .10), so that the increase in yields of milk fat, lactose and solids paralleled the increases in milk yield. Total milk protein yield tended to be higher in sows receiving pST, but protein yield was greater (P < .10) only on d 28. Pigs suckling sows treated with pST weighed .34 kg more at the end of the lactation period (P < .05). Sows receiving pST consumed less feed (P < .05) during the treatment period, and, as a result, lost more weight (P < .10) and backfat (P < .05) than control sows. Average concentrations of plasma somatotropin were elevated approximately 2.5-fold above baseline levels by exogenous pST. No acute alterations in plasma glucose or nonesterified fatty acids were observed in response to pST treatment, however, sows receiving pST had a chronic elevation of plasma glucose on d 29 of lactation.

¹ Dept. of Anim. Sci.

² Supported by Cornell Univ. Agric. Exp. Sta. and American Cyanamid Co. Portions of this paper were presented at die Cornell Nutr. Conf. in Syracuse, NY, 1985 and at the 77th Annu. Mtg. of the Am. Soc. of Anim. Sci. in Columbia, MO (abstract published in J. Anim. Sci. 61[Suppl. 1]:316).

³ The authors gratefully acknowledge W. R. Butler and K. Plaut for assistance with radioimmunoassay, G. Kolb for care of the animals, T. Bui for assistance in sample analysis, and D. Ceurter for preparation of the manuscript.

⁴ To whom reprint requests should be directed (252 Morrison Hall).

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