J. Anim Sci.
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J. Anim Sci. 1989. 67:1489-1496.
© 1989 American Society of Animal Science
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Fate and Residues of Trenbolone Acetate in Edible Tissues from Sheep and Calves Implanted with Tritium-Labeled Trenbolone Acetate1

P. Evrard2, G. Maghuin-Rogister2 and A. G. Rico3

University of Liege, Belgium and National Veterinary School of Toulouse, France

Abstract

In order to study the fate and residues of trenbolone acetate in edible tissues, two groups of six animals from two ruminant species (ewes and calves) were implanted with [3H]trenbolone acetate. The distribution of extractable radioactive residues was measured in liver, kidney and muscle. We found that the largest proportion of residues was not extractable and thus was considered as covalently bound residues. The proportion of the main extractable metabolites (17{alpha}-trenbolone, trendione, 17ß-trenbolone) was measured. The evaluation of the distribution of trenbolone acetate metabolites directly soluble in water showed that unknown metabolite(s) were predominant. The covalent binding to nucleic acids was measured. It was so low that it was not detectable. The results are discussed in light of the data presented in the scientific report on anabolic agents in animal production from the European scientific working group.

Footnotes

1 This research was supported by the Belgian "Institut pour l'encouragement de la Recherche Scientifique dans l'industrie et l'Agriculture (IRSIA)" (Belgium) and by the "Institut National de la Recherche Agronomique (INRA)" (France).

2 Lab. for the Anal. of Food from Anim. Origin, Faculty of Vet. Med., rue des Vétérinaires, 45 B-1070 Brussels, Belgium.

3 Biochem. and Metab. Toxicol. Lab. INRA, Chemin des Capelles 23 F-31076 Toulouse, Cedex, France.






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Copyright © 1989 by the American Society of Animal Science.