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Effect of Fenbendazole¹ and Pyrantel Tartrate^,2 on the Induction of Protective Immunity in Pigs Naturally or Experimentally Infected with Ascaris suum^,3,4,

Louisiana State University Agricultural Center and School of Veterinary Medicine, Baton Rouge 70803

Abstract

An experiment was conducted with 96 weanling pigs (avg initial wt 18.5 kg) divided into six treatment with two replicates of eight pigs each. Pigs in Treatments 1, 2 and 3 were penned in outside pens with dirt lots that previously were contaminated with A. suum ova to induce a natural ascaris infection. Pigs in Treatments 4, 5 and 6 were penned in an open-front building with solid concrete floors and were experimentally infected with 2,000 embryonated A. suum. ova on d 1, 15 and 29 of the experiment. Pigs in Treatments 1 and 4 were medicated with fenbendazole (FBZ, 3 mg/[kg BW·d]) for three consecutive days during three consecutive time periods. Pigs in Treatments 2 and 5 were medicated with pyrantel tartrate (PT, 106 mg/kg feed) for 28 d. Pigs in Treatments 3 and 6 served as infected, unmedicated controls. All pigs were challenged with 100 A. suum eggs 7 d after termination of the final FBZ treatment. All pigs were killed 66 d after challenge and worms were recovered. Fenbendazole treatment resulted in greater (P < .07) average daily gain than PT treatment in pigs penned outside. Among inside pigs, FBZ treatment resulted in better (P < .02) feed utilization than in controls. The FBZ and PT treatments reduced (P < .03) the total number of A. suum, the length and weight of female ascarids and the length of male ascarids compared with controls. A natural continual infection with A. suum was less effective than experimental infection in inducing protective immunity in pigs.

¹ Safe-Guard®, Hoechst-Roussel Agri-Vet Company, Somerville, NJ.

² Banminth®, Chas. Pfizer and Company, Inc., Terre Haute, IN.

³ Approved for publication by the Director of the Louisiana Agric. Exp. Sta. as manuscript No. 87-11-1416.

⁴ Supported in part by Hoechst-Roussel Agri-Vet Co., Somerville, NJ.

⁵ Address reprint requests to Dr. L. Lee Southern, Dept. of Anim. Sci., Louisiana State Univ., Baton Rouge 70803.

⁶ Dept. of Vet. Microbiol. and Parasitol., Louisiana State Univ. School of Vet. Med.

⁷ Dept. of Vet. Clinical Sci., Louisiana State Univ. School of Vet. Med.