HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Stabel, J. R. Articles by Brake, J. Search for Related Content PubMed PubMed Citation Articles by Stabel, J. R. Articles by Brake, J.

Selenium Effects on Glutathione Peroxidase and the Immune Response of Stressed Calves Challenged with Pasteurella Hemolytica^1,2,

North Carolina State University, Raleigh 27695-7621

Abstract

The present study was conducted to determine whether a marginal Se deficiency affects health, blood characteristics and the immune response of calves subjected to stresses associated with weaning, shipping (332 km) and Pasteurella hemolytica inoculation. Treatments were 1) –Se, 2) –Se/P. hemolytica, 3) +Se (.1 mg Se/kg feed) and 4) +Se/P. hemolytica. Previous Se intake was controlled; dams of –Se calves were fed diets marginally deficient in Se (.03 to .05 mg/kg), whereas dams of +Se calves received a s.c. injection of 30 mg Se (as sodium selenite) every 60 d. Calves were inoculated with P. hemolytica intratracheally on d 3 following weaning and transport. Inoculation with P. hemolytica increased (P < .05) body temperatures, platelet counts, serum IgM concentrations and serum antibody titers and decreased serum albumin concentrations at 4 to 7 d postinoculation. Weight gains for the 21-d study were not affected by Se status, although whole blood and plasma glutathione peroxidase (GSH-Px) were higher (P < .05) for +Se calves. Plasma GSH-Px increased (P < .01) in calves showing signs of morbidity. Increases in plasma GSH-Px were correlated positively with body temperature. Serum IgM concentrations were higher (P < .05) in +Se calves on d 17, but Se-supplemented calves had lower (P < .05) anti-P. hemolytica titers on d 17 than –Se calves. Selenium status did not affect body temperatures, plasma creatine phosphokinase or serum IgG and albumin concentrations. These results indicate that Se status can affect IgM concentrations following stress.

¹ Paper No. 11682 of the journal series of the North Carolina ARS, Raleigh 27695-7601. Use of trade names in this publication does not imply endorsement by the North Carolina ARS or criticism of similar products not mentioned.

² Supported in part by USDA Grant No. 82CRSR-2-1054. The authors wish to thank A. W. Confer for his help in the determination of P. hemolytica antibody titers.

³ Present address: National Animal Disease Center, USDA, ARS, Ames, IA 50010.

⁴ Dept. of Anim. Sci. and the Interdept. Nutr. Program.

⁵ Address reprint requests to this author.

⁶ Dept. of Vet. Microbiol. Pathol. and Parasitol.

⁷ Dept. of Poult. Sci.