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Acute Changes in Blood Flow in Pigs Infused with ß-Adrenergic Agonists

U.S. Department of Agriculture Clay Center, NE 68933^1,2,3,

Abstract

Previous results indicate that clenbuterol decreases carcass adipose tissue accretion when administered to pigs but does not appear to stimulate the adipose tissue ß-adrenergic receptor. Clenbuterol increases plasma free fatty acid concentration when acutely infused in vivo, suggesting an indirect affect. One possible indirect effect is that clenbuterol could change blood flow to adipose tissue. Blood flow was measured with radiolabeled microspheres in tissues from pigs before and after infusion of a ß-adrenergic agonist for 30 min. High probability levels (up to P < .2) were used to indicate trends due to extreme variability. Infusion of isoproterenol increased heart rate, plasma free fatty acid concentration and blood flow at many adipose tissue sites and at a few skeletal muscle sites. Infusion of isoproterenol decreased blood pressure. Infusion of clenbuterol increased heart rate and tended to increase blood flow to several skin and adipose tissue sites slightly. The results suggest that increased adipose tissue blood flow may contribute to the accelerated release of free fatty acids when clenbuterol is infused acutely in vivo.

¹ Roman L. Hruska U.S. Meat Anim. Res. Center, ARS.

² I thank L. J. Robinson for execution and analysis of these experiments, B. E. Larsen for care and handling of pigs, M D. MacNeil for statistical consultation, and C. C. Grummert, M. M. Bierman, D. A. George and J. R. Watts for secretarial assistance.

³ Mention of trade names, proprietary products or specific equipment does not constitute a guarantee or warranty of the product by the USDA and does not imply its approval to the exclusion of other products that may also be suitable.