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Immune, Growth and Carcass Responses of Ram Lambs to Active Immunization against Desulfated Cholecystokinin (CCK-8)¹

U.S. Department of Agriculture^,3, Clay Center, NE 68933

Abstract

This study explored feed intake and carcass responses to active immunization against desulfated cholecystokinin-octapeptide (CCK-8) in ram lambs. Antibody titers 8 wk following primary immunization and booster immunizations given at 4 and 6 wk averaged greater than 1:1,000. Titers increased to greater than 1:10,000 by 16 wk following a final booster immunization at 11 wk. The antibodies developed against desulfated CCK-8 exhibited 29% and 13% cross-reactivities for sulfated CCK-8 and gastrin-17, respectively. Immunization against desulfated CCK-8 had no effect on feed intake, ADG, carcass weight or carcass quality grade. Backfat thickness and carcass yield grade were reduced (P < .05) by immunization. Organ weights at slaughter, including those of the pancreas and small intestines, were not affected by CCK-8 immunization, with the exception of the lungs, which were 16% lighter (P < .01) in immunized lambs. In conclusion, active immunization against desulfated CCK-8 resulted in development of high antibody titers against desulfated and sulfated CCK-8. Immunization against CCK-8 decreased fat content of the carcass but failed to affect feed intake, carcass weight or ADG.

¹ The authors are grateful to George McMillan and Sue Wise for their technical assistance during this study and to Bruce Larsen and Lynn Laaker for care and feeding of the animals and assistance with record keeping. Thanks also are extended to Dave Kohmetscher and the abattoir staff for the collection of carcass data and to Debbie Brown and Donna Griess for typing this manuscript.

² Reprint requests: Roman L. Hruska U.S. Meat Anim. Res. Center, ARS-USDA, Clay Center, NE 68933.

³ Mention of trade names or companies does not constitute an implied warranty or endorsement by the authors or USDA.