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Influence of Infused ß-Adrenergic Agonists on Porcine Blood Metabolites and Catecholamines

U.S. Department of Agriculture^1,2,3,, Clay Center, NE 68933

Abstract

Anesthetized pigs were infused sequentially with increased concentrations of ß-adrenergic agonists. At selected times during infusion, blood pressure, heart rate and plasma concentrations of free fatty acids (FFA), glycerol, glucose, lactate, norepinephrine, epinephrine and dopamine were measured. Azaperone, a drug used to calm the pigs before anesthesia, caused hypotension and bradycardia but did not affect plasma metabolites. Infusion of norepinephrine, epinephrine, isoproterenol or clenbuterol produced changes in plasma metabolites and plasma catecholamines. These changes during norepinephrine infusion were attributed to the infused agonist, whereas those during epinephrine infusion might have resulted to some extent from release of norepinephrine. Plasma isoproterenol was not quantified because it interfered with the assay of epinephrine and dopamine so that it was not possible to distinguish between infused isoproterenol and release of endogenous epinephrine and dopamine. Infusion of clenbuterol caused a small increase in plasma norepinephrine so that some of the increase in plasma FFA, glycerol and lactate during clenbuterol infusion may result from release of endogenous norepinephrine.

¹ ARS, Roman L. Hruska Meat Anim. Res. Center.

² I especially thank L. J. Robinson for execution and analysis of these experiments. I also thank C. J. Smith for technical assistance, M. D. MacNeil for statistical consultation, B. E. Larsen for care and handling of animals and M. M. Bierman, D. B. George, J. R. Watts and C. C. Grummert for secretarial assistance.

³ Mention of a trade name, proprietary product or specific equipment does not constitute a guarantee or warranty of the product by the USDA and does not imply its approval to the exclusion of other products that may also be suitable.