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Effects of Time and Dietary Selenium Concentration as Sodium Selenite on Tissue Selenium Uptake by Sheep^1,2,

University of Florida^,5, Gainesville 32611

Abstract

Thirty crossbred wethers (60 kg avg initial wt) were used to study the time-dose response to dietary Se as sodium selenite (Na₂ SeO₃). Sheep were fed a basal diet (.20 mg/kg Se, DM basis) for 10 d; three wethers were killed and tissues were collected for controls. The remaining 27 sheep were assigned randomly to diets supplemented with either 3, 6 or 9 mg/kg Se (as-fed basis) from reagent grade Na₂ SeO₃ and fed for 10, 20 or 30 d. Feed offered was restricted to 1,200 g daily and tap water was available ad libitum. Sheep were stunned and killed by exsanguination and liver, kidney, muscle, heart and spleen were removed and frozen for Se analysis. No toxic effects were noted as expressed by feed intake or hemoglobin concentration. Added dietary Se increased Se linearly (P < .01) in liver, kidney, and serum. Selenium in liver, kidney and serum also increased (P < .01) as time advanced. Serum, liver and kidney were more sensitive to dietary Se than were muscle, heart and spleen. Ten days appeared to be an adequate length of time for further Se bioassay studies of this nature. Reagent grade Na₂ SeO₃ was nontoxic when fed to sheep for 30 d at levels up to 90 times the Se requirement.

¹ Florida Agric. Exp. Sta. journal ser. no. 8562.

² The authors wish to acknowledge Ajay Chemical Co., Powder Springs, GA, Pitman-Moore Inc., Mundelein, IL, Moorman Manufacturing Co., Quincy, IL and Occidental Chemical Co., Tampa, FL for funds in support of this research; Pfizer, Inc., New York for supply ing vitamins and Monsanto Chemical Co., St. Louis, MO for supplying ethoxyquin.

³ Present address: I.V.I.T.A., Universidad Nacional Mayor de San Marcos, P. O. Box 4270, Lima, Peru.

⁴ Dept. of Statistics.

⁵ Dept. of Anim. Sci.

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