J. Anim Sci.
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J. Anim Sci. 1988. 66:1393-1400.
© 1988 American Society of Animal Science
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Effect of Cimaterol on Sheep Adipose Tissue Lipid Metabolism1

C. Y. Hu2,3,, A. Suryawan2, N. E. Forsberg2, R. H. Dalrymple4 and C. A. Ricks4

Oregon State University, Corvallis 97331 and American Cyanamid Co., Princeton, NJ 08540

Abstract

Effects of dietary cimaterol (5 mg/kg) on adipose tissue metabolism of wether lambs were studied. Lipogenesis, lipolysis, fatty acid composition and adipocyte size and number were measured. Cimaterol feeding increased lipogenesis; however, this effect was not statistically significant. Insulin (1,000 µU/ml) stimulated lipogenesis of adipose tissue from control sheep. However, this elevated rate was abolished by in vitro cimaterol. Insulin had no stimulatory effect on lipogenesis in cimaterol-fed sheep. Lipolysis was depressed by cimaterol feeding. However, 10-4 M cimaterol stimulated lipolysis in the adipose tissue from both control and cimaterol-fed sheep. Insulin inhibited stimulated lipolysis in adipose tissue from control sheep but had no effect on the stimulated lipolysis in cimaterol-fed sheep. Mean adipocyte diameter was smaller (from 74 to 70 µm) and adipocyte size distribution also was changed in the cimaterol-fed sheep. Adipocyte number per gram of tissue was not affected by cimaterol. There was a significant increase in percentage of unsaturated fatty acids in adipose tissue from cimaterol-fed sheep. These results indicate that lipogenic and lipolytic responses to insulin and cimaterol in sheep adipose tissue were altered by cimaterol feeding. The carcass fat content decrease in cimaterol-fed sheep may be attributed to the reduction in adipocyte size.

Footnotes

1 Tech. paper no. 8312, Oregon State Exp. Sta.; the authors thank Dr. L. J. Koong for statistical consultation, N. B. Wehr for technical assistance and D. L. Martin for secretarial assistance.

2 Dept. of Anim. Sci.

3 Reprint requests.

4 American Cyanamid Co., Agric. Res. Div.






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Copyright © 1988 by the American Society of Animal Science.