J. Anim Sci.
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J. Anim Sci. 1987. 65:1602-1609.
© 1987 American Society of Animal Science
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Effects of Exogenous Estradiol-17ß and Progesterone on Naloxone-Reversible Inhibition of the Release of Luteinizing Hormone in Ewes1,2,

W. E. Trout and P. V. Malven

Purdue University3, West Lafayette, IN 47907

Abstract

The role of endogenous opioids in controlling luteinizing hormone (LH) secretion was studied by injecting the opioid antagonist naloxone into intact and ovariectomized ewes that were treated with estradiol-17ß (E2) and progesterone (P4). The existence of a naloxone-reversible inhibition of LH release was examined in five experiments using a total of 52 mature ewes. Naloxone at a dosage of 1 mg/kg disinhibited release of LH and abruptly increased serum concentrations of LH in a variety of experimental models. This naloxone-reversible inhibition of LH secretion was apparent in all experimental models that involved P4-induced inhibition of basal LH secretion but not in one model in which P4 inhibited the LH surge. Specific effects of E2 on naloxone-reversible inhibition of LH varied among experimental models. When prolonged administration of P4 alone appeared to lose its LH-inhibitory potency, E2 restored inhibition of LH as well as the naloxone-reversible state. Whenever E2 acted synergistically to suppress basal LH secretion in models involving brief (5 d) exposure to P4, E2 appeared to antagonize the naloxone-reversible state. In summary, P4-induced suppression of LH secretion appeared to be mediated by endogenous opioids, but the apparent interaction of E2 and opioids in LH suppression varied among experiments.

Footnotes

1 Published as journal paper no. 11,071, Purdue Univ. Agric. Exp. Sta. The authors appreciate the assistance of D. W. Gregg, C. C. Chao, S. A. Haglof, G. E. Moss and T. L. Roberson.

2 Portions of these results have been reported previously in preliminary form [J. Anim. Sci. 59 (Suppl. 1):34 and J. Anim. Sci. 61 (Suppl. 1):392].

3 Dept. Anim. Sci.






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Copyright © 1987 by the American Society of Animal Science.