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Effects of Physiologic and Pharmacologic Agents on Serum Prolactin Concentrations in the Nonpregnant Mare^1,2,

Rutgers University³, New Brunswick, NJ 08903

Abstract

Four studies were conducted to evaluate the effects of several physiologic and pharmacologic agents on serum prolactin concentrations in the nonpregnant mare. An increase in prolactin measured in response to administration of thyrotropin-releasing hormone (TRH; 50 µg, iv) was found not to vary (P=.20) in mares in estrus compared with mares in diestrus (5 to 10 d post-ovulation). Administration in the dopamine receptor blocker, metoclopramide (25 or 100 mg, im), rapidly increased serum prolactin, and the response was dependent on dose administered (total prolactin measured for 420 min was 3,362.7 ± 182.1 ng for 25 mg, and 4,485.7 ± 212.6 ng for 100 mg administered im; P<.05), but not on route of injection (3,026.3 ± 492.3 ng prolactin with 25 mg, iv; P<.05). Similarly, sulpiride, a D-2 dopamine receptor blocker, induced an increase in serum prolactin, which appeared to be maximal at a dose of 25 mg (6,556.3 ± 636.9 ng prolactin/420 min compared with 6,594.5 ± 169.3 ng prolactin/420 min with 100 mg sulpiride; P>.10). Finally, bromocriptine, a dopamine agonist, decreased serum prolactin compared with vehicle-injected controls, but the inhibitory effect was found only when basal levels of serum prolactin were highest (in May). These data suggest that mechanisms controlling prolactin secretion in the mare are similar to those described in other mammalian species, and that the seasonal decline in serum prolactin is not the result of increased sensitivity to the proposed prolactin-inhibiting factor, dopamine.

¹ Publication D-06106-01-87 of the New Jersey Agric. Exp. Sta.

² The authors thank Ms. C. Brown and D. Richard for excellent technical assistance and Ms. C. J. Uckele for typing the manuscript.

³ Dept. Anim. Sci.