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Effect of Efrotomycin on Gain and Feed Efficiency for Pigs from Weaning until Market Weight^1,2,3,

Merck Sharp & Dohme Research Laboratories, Rahway, NJ 07065

Abstract

Six studies involving 700 pigs were conducted in five separate swine research facilities to evaluate weight gain and efficiency of feed utilization in pigs fed the antibiotic efrotomycin. Pigs averaging 8.4 kg at the beginning of the studies were fed fortified corn-soybean meal diets that contained efrotomycin at 0, 2, 4, 8 or 16 ppm for an average of 120 d to market weight, about 92.1 kg. Pigs fed efrotomycin gained 5.9 to 8.9% faster (P<.01) and were 1.7 to 4.0% more efficient (P<.01) than those fed control diets. The improvement in growth rate was linear from 2 through 16 ppm, while feed efficiency (gain/feed) plateaued at 4 ppm efrotomycin. Treatment x study interactions were not significant for average daily gain or feed efficiency, showing that the response to efrotomycin was similar in each study. These studies indicate that efrotomycin is effective in improving gain and efficiency of feed utilization in swine from weaning until market weight.

¹ Studies supported in part by Merck Sharp & Dohme Res. Lab., Division of Merck & Co., Inc., Rahway, NJ 07065.

² Efrotomycin is an investigational new animal drug that is not currently cleared by the Food and Drug Admin. for use in swine.

³ The authors gratefully acknowledge the following for assistance in the successful completion of these studies: M. S. Edmonds, Dept. of Anim. Sci., Univ. of Illinois; T. S. Stahly and H. J. Monegue, Dept. of Anim. Sci., Univ. of Kentucky; K. Watkins, Dept. of Anim. Sci., Univ. of Missouri and L. Underwood, Dept. of Anim. Sci., Purdue Univ.

⁴ Dept. of Anim. Sci., Univ. of Illinois, Urbana, IL 61801.

⁵ Dept. of Anim. Sci., Purdue Univ., West Lafayette, IN 47907.

⁶ Dept. of Anim. Sci., Univ. of Kentucky, Lexington, KY 40546.

⁷ Dept. of Anim. Sci., Univ. of Missouri, Columbia, MO 65211.

⁸ Merck Res. Farm, Fulton, MO 65251.