J. Anim Sci.
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J. Anim Sci. 1987. 65:1013-1018.
© 1987 American Society of Animal Science
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Effects of a Dietary Antimicrobial (Carbadox) on Liver Cholesterol 7{alpha}-Hydroxylase Activity and Bile Acid Patterns in the Young Pig

J. D. Tracy1 and A. H. Jensen2,3,

University of Illinois, Urbana 61801

Abstract

Two experiments were conducted to investigate the effects of the antimicrobial carbadox (CX) on bile acid metabolism in the young pig. The pigs were fed a fortified, 19.5% crude protein, corn-soybean meal diet without or with 55 ppm CX. In Exp. I pigs were fed the diets for 28 d, then the level of activity of hepatic cholesterol 7{alpha}-hydroxylase (CH-7{alpha}), the rate-limiting enzyme of bile acid metabolism, was measured. The CX-fed pigs gained faster (P<.05) and more efficiently (P< 05) and had lower (P<.02) CH-7{alpha} activity than the control pigs. In Exp. II, pigs ranging in weight from 12 to 15 kg were fitted with indwelling catheters in the hepatic portal (HP) and anterior vena cava (VC) veins. Radiolabeled chenodeoxycholic acid (CDC) was infused into the HP and blood samples from both veins were taken at meal time and hourly for 6 h following six meals over 3 d. Bile was collected 14 d after infusion. Concentrations of lithocholic acid (LC) in the bile and hyodeoxycholic acid (HDC) in the plasma were reduced by dietary CX. Dietary CX did not significantly affect metabolism of plasma CDC or hyocholic acid (HC) as measured by radioactivity. Meal time (0800 vs 1600) affected (P<.05) plasma CDC radioactivity at all times and the level of HDC radioactivity 2 h post-prandial. There was a meal time x dietary treatment interaction (P<.02) on plasma HC radioactivity 2 h post-prandial. These data suggest that dietary CX inhibited intestinal microbial degradation of CDC and HC.

Footnotes

1 Present address: 4108 120th, N.W., Coon Rapids, MN 55433.

2 Dept. of Anim. Sci.

3 To whom reprint requests should be made.






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Copyright © 1987 by the American Society of Animal Science.