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North Carolina State University, Raleigh 27695-7621
Abstract
Two experiments determined how feed restriction and realimentation altered metabolism and ovarian function in gilts. In Exp. 1, cyclic (INTACT-R, n=6) and ovariectomized (OVEX-R, n=6) gilts were fed restricted diets (.23 kg feed·d–1) or ovariectomized (OVEX-C, n=6) gilts were fed control diets (1.81 kg·d–1). Estrous cycles stopped after 46 ± 9 d of feed restriction. Average weight (WT), backfat thickness (BF) and concentrations of insulin (INS) were lower and free fatty acids (FFA) were greater in OVEX-R than in OVEX-C gilts. Frequency of luteinizing hormone (LH) release (peaks·6 h–1) was reduced by feed restriction (.2 ± .2, 1.8 ± 1.0 and 5.8 ± .2 in INTACT-R, OVEX-R and OVEX-C gilts, respectively). Patterns of secretion of LH and follicle stimulating hormone (FSH) after gonadotropin releasing hormone (GnRH) or estradiol benzoate were not altered by feed restriction. Feed intake was then increased in INTACT-R and OVEX-R gilts beginning on d 80 and 82, respectively. Resumption of estrous cycles in INTACT-R gilts occurred on d 116.0 ± 4.0 and was preceded by a significant increase in WT, but not BF, and a linear increase in concentration and frequency of release of LH. Increasing feed intake in OVEX-R gilts increased WT and frequency of LH release, while FFA decreased and INS increased to concentrations not different from those of OVEX-C gilts. The hypothesis that nutritionally-induced anestrus resulted from decreased activity of the hypothalamic pulse-generator was evaluated in Exp. 2 by providing 144 hourly pulses (iv) of saline (n=3), GnRH (n=3) or LH (n=4) to nutritionally-anestrous gilts. Pulsatile administration of LH or GnRH increased basal concentration and frequency of LH and estradiol. Preovulatory-type surges of LH and FSH occurred in three of three GnRH-treated and zero of four LH-treated gilts; preovulatory-sized follicles or corpora hemmorrhagica were present at ovariectomy in LH- and GnRH-treated gilts, but not in saline-treated gilts. In conclusion, chronic feed restriction altered ovarian activity in the pig by altering hypothalamic release of GnRH.
1 Paper no. 10550 of the Journal Series of the North Carolina Agr. Res. Serv, Raleigh. The use of trade names in this publication does not imply endorsement by the North Carolina Agr. Res. Serv. of the product named, nor criticism of similar ones not mentioned. The authors acknowledge R. Hand, V. Hedgpeth and R. Scott for excellent technical assistance; M. Galloway and S. Mizelle for preparing the manuscript; and N. R. Mason, G. D. Niswender and D. J. Bold for supplying antisera and hormones for assays.
2 Dept. of Anim. Sci., North Carolina State Univ., Box 7621, Raleigh, NC 27695-7621.
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