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Bovine Corpus Luteum Regression and Estrous Response Following Treatment with Alfaprostol^1,2,3,4,

Texas Agricultural Experiment Station^,6, Overton 75684

Abstract

Two trials evaluated bovine corpus luteum (CL) regression and estrous response following treatment with alfaprostol (AP), a prostaglandin F₂ analogue. Expression of at least one estrous cycle (16 to 26 d) and a palpable mid-cycle CL were required prior to random assignment of females to receive 0, .38, .75, 1.50 or 2.25 mg AP/100 kg body weight. Alfaprostol was evaluated in Brahman cows and heifers that were treated on d 11 to 13 (trial 1) and in Simmental x Brahman-Hereford (crossbred) heifers that were treated on d 8 to 10 or d 11 to 13 of the estrous cycle (trial 2). In trial 1, Brahman heifers appeared to require a higher AP dose (>.38 mg/100 kg body weight) to elicit luteolysis and expression of estrus than Brahman cows. Alfaprostol treatment (.75 mg/100 kg body weight) induced (P<.0001) luteolysis followed by estrus in Brahman cows and heifers. In trial 2, crossbred heifers that received AP on d 8 to 10 appeared to require a higher dose of AP (>.38 mg/100 kg body weight) to elicit luteolysis and estrus than heifers that received AP on d 11 to 13 of the estrous cycle. Alfaprostol treatment >.75 mg/100 kg body weight on d 8 to 10 and d 11 to 13 of the estrous cycle induced (P<.0001) luteolysis followed by estrus in crossbred heifers. Alfaprostol may be used to induce luteolysis and estrus when administered at doses .75 mg/100 kg body weight in Brahman cows and heifers and crossbred heifers.

¹ Journal paper TA 20762, Texas Agr. Exp. Sta.

² This study was a contribution to Western Regional Project W-112, Reproductive Performance in Domestic Ruminants.

³ This study was supported in part by a grant from Hoffmann-LaRoche, Inc., Nutley, NJ.

⁴ The authors express their gratitude to Janis Williamson for typing of the manuscript.

⁵ Hoffmann-LaRoche, Inc., Nutley, NJ.

⁶ Texas A&M Univ. Agr. Res. and Ext. Center.