J. Anim Sci.
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J. Anim Sci. 1987. 64:797-804.
© 1987 American Society of Animal Science
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Passive Immunization of Cyclic Mares Against Androgen: Gonadotropin and Progesterone Concentrations and Estrous Characteristics

D. L. Thompson, Jr.1, J. J. Wiest, F. Garza, Jr., K. B. Ashley and D. R. McNeill

Louisiana State University Agricultural Center2, Baton Rouge 70803

Abstract

Antiserum generated in a horse against testosterone conjugated to bovine serum albumin (BSA) was administered to six lighthorse mares (androgen-immunized mares) 1 to 3 d before a pros-taglandin-induced estrus and twice again at 2-d intervals. Six control mares were administered antiserum generated against BSA on the same schedule. Relative to testosterone, cross-reactivities of other steroids with the testosterone antiserum were (%): dihydrotestosterone, 52; 5{alpha}-androstane-3{alpha},17ß-diol, 8.6; androst-4-ene-3,17-dione, 1.2; and all others tested <.l. Tritiated testosterone binding in plasma increased (P<.01) in androgen-immunized mares within 1 h and remained elevated (P<.01) relative to controls for >21 d. There was no effect (P>.10) of passive immunization against androgen on interval to estrus after prostaglandin injection, duration of estrus, ovarian volume, number of palpable follicles or follicular volume during estrus. In contrast, concentrations of luteinizing hormone (LH) were higher (P<.05) in androgen-immunized mares than in control mares during estrus and early diestrus. Concentrations of follicle stimulating hormone (FSH) and progesterone at those times were not affected (P>.10). From these data, we conclude that androgens in the mare during estrus may be involved with the regulation of LH secretion. In contrast, no involvement with FSH secretion was apparent under these short-term conditions.

Footnotes

1 Send reprint requests to D. L. Thompson, Jr., Anim. Sci. Dept., Louisiana State Univ., Baton Rouge, LA 70803.

2 Anim. Sci. Dept., Louisiana Agr. Exp. Sta.






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Copyright © 1987 by the American Society of Animal Science.