HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Shanks, R. D. Articles by Robinson, J. L. Search for Related Content PubMed PubMed Citation Articles by Shanks, R. D. Articles by Robinson, J. L.

Deficiency of Uridine Monophosphate Synthase in Holstein Cattle: Inheritance and Body Measurements^1,2,

University of Illinois, Urbana 61801

Abstract

Blood samples and body measurements were obtained from daughters of seven Holstein bulls previously shown to have a partial deficiency of uridine monophosphate (UMP) synthase and presumed to be heterozygous for the condition. Erythrocyte UMP synthase for 85 daughters showed a bimodal distribution with 42 having half the normal activity of 43 others. Furthermore, each bull had 50% of his daughters represented in each group, a finding fully consistent with the heterozygous designation of these bulls. Because UMP synthase is needed for pyrimidine biosynthesis and hence DNA and RNA metabolism, it was hypothesized that a partial deficiency could result in slower growth and smaller size for affected animals. Body measurements, as estimates of growth and size, included body length, wither height, hip height, hip width, rump length, pin width and taped body weight. Although measurements varied by age, differences between normal and heterozygous females were not found. One-half the normal activity of UMP synthase in cattle was adequate for near normal growth. Additionally, herd life was not significantly affected in heterozygous females.

¹ Made possible by suppport from the Illinois Agr. Exp. Sta. and the Holstein Assoc. of America.

² Authors gratefully acknowledge the cooperation of artificial insemination companies and the Holstein Assoc. for providing pedigree information. They thank the dairy producers who permitted the testing of their animals. They appreciate the assistance provided by K. K. Harden, M. A. Greiner and D. M. Menefee in preparing this manuscript.

³ Dept. of Anim. Sci.

⁴ To whom reprint requests should be addressed: Univ. of Illinois, 315 Anim. Sci. Lab., 1207 W. Gregory Drive, Urbana, IL 61801.