J. Anim Sci.
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J. Anim Sci. 1986. 63:1502-1508.
© 1986 American Society of Animal Science
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Effects of Slaframine on Ruminant Digestive Function: Ruminal Motility in Sheep and Cattle1

M. A. Froetschel2,3,4,, W. J. Croom, Jr.2,5,6,, W. M. Hagler, Jr.7, R. Argenzio6, J. Liacos6 and H. P. Broquist8

North Carolina State University, Raleigh 27695 and Vanderbilt University, Nashville, TN 37232

Abstract

Effect of purified slaframine (SF; 1-acetoxy-6-aminooctahydroindolizine), a parasympathomimetic secretagogue isolated from Rhizoctonia leguminicola, on ruminal motility was investigated in cattle and sheep. In trial 1, four ruminal cannulated wethers, fed a pelleted concentrate and hay diet, were injected intramuscularly with 0, 12, 24 and 48 µg SF/kg body weight (BW) in a 4 x 4 Latin-square design. Ruminal motility was recorded 1 h before and 1 to 2 h and 3 to 4 h after SF administration by measuring pressure changes exerted upon a fluid-filled, open-tipped catheter inserted into the dorsal sac of the rumen. The frequencies of both primary and secondary ruminal contractions were decreased as much as 20 to 78% with SF (P<.05) depending upon the dosage level and time after administration. In trial 2, three ruminal-cannulated steers fed a concentrated diet were injected intramuscularly with 0, 12 and 24 µg SF/kg BW in a 3 x 3 Latin-square design. A water-filled balloon inserted into the cranial sac of the rumen was used to measure ruminal pressure changes 1 h before and 1 to 2 h, 3 to 4 h and 7 to 8 h after SF administration. Frequency of primary and secondary ruminal contractions decreased with SF as much as 27 to 64% depending on the dosage level and time after administration. The frequency of secondary contractions increased 28% (P<.05) as compared with control during the 7 to 8 h after administration. Because of the known stimulatory effect of SF on salivation, its actions upon ruminal motility suggest that different populations of cholinergic receptors exist in ruminant salivary glands and ruminal smooth muscle.

Footnotes

1 Paper No. 10243 of the Journal Series of the North Carolina Agr. Res. Serv., Raleigh, NC 27695-7601. The use of trade names in this publication does not imply endorsement by the North Carolina Agr. Res. Serv. of the products named, nor criticism of similar ones not mentioned.

2 Animal-Forage Metab. Complex, Dept. of Anim. Sci., North Carolina State Univ.

3 Part of a thesis submitted to the Graduate College of North Carolina State Univ. in partial fulfillment of the requirements for the Ph.D. degree in Anim. Sci.

4 Present address: Dept. of Anim. and Dairy Sci., Univ. of Georgia, Athens.

5 Address correspondence to this author.

6 Dept. of Anat., Physiol. Sci and Radiol., North Carolina State Univ.

7 Dept. of Poul. Sci., North Carolina State Univ.

8 Dept. of Biochem., Vanderbilt Univ. Supported by Public Health Service Grant ES00S69 from the Natl. Inst. of Health.






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Copyright © 1986 by the American Society of Animal Science.