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Dose-Response Shift in the Ability of Gilts to Remain Pregnant Following Exogenous Estradiol-17β Exposure¹

University of Wisconsin^,2, Madison 53706 and Cornell University^,3, Ithaca, NY 14850

Abstract

Sixty mated gilts were assigned to a 2 x 6 factorial arrangement (n = 5) of day of injection (d 9 and 10 vs 12 and 13; d 0 = first day of estrus) and dose of estradiol-17β (0, .125, .5, 2, 8 and 32 mg·gilt^–1·d^–1). Gilts were subsequently slaughtered on d 30; pregnancy was verified and percent embryonic survival calculated. A 64-fold shift in the dose-response curve for percent embryonic survival illustrated that the adverse effects of exogenous estradiol-17β were less when administered on d 12 and 13 as compared with d 9 and 10 (day x dose, P<.01). This experiment demonstrated that the uterine-embryonic environment of d 12 and 13 pregnant gilts was more tolerant of exogenous estrogen alterations than that of d 9 and 10 pregnant gilts.

¹ Dept. of Meat and Anim. Sci. Paper No. 987. Research was supported by the College of Agr. and Life Sci., Univ. of Wisconsin, Madison and a grant from the W. R. Grace Co.

² Dept. of Meat and Anim. Sci., Univ. of Wisconsin, Madison 53706.

³ Dept. of Anim. Sci., Cornell Univ., Ithaca, NY 14850.

⁴ Reprint requests to William Pope, The Ohio State Univ., Dept. of Anim. Sci., 2029 Fyffe Road, Columbus, OH 43210.

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