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Age, Dose of FSH and Other Factors Affecting Superovulation in Holstein Cows¹

West Virginia University, Morgantown 26506-6302 and Select Embryos, Inc., Plain City, OH 43064

⁷ To whom requests for reprints should be sent.

Abstract

Effects of age of donor and other factors on superovulation and production of transferable embryos were investigated. Data were obtained on 987 recoveries of embryos performed between November 1980 and June 1984 by Select Embryos, Inc. The 339 Holstein donors ranged in age from 1.8 to 17.8 yr. The effects of age of donor and dose of follicle stimulating hormone (FSH) were examined using regression analysis. For on-farm recoveries, numbers of embryos, rates of fertilization, quality scores of all embryos and numbers of transferable embryos decreased (P<.01, P<.001, P<.05, P<.01, respectively) with increasing age of donor. For in-clinic recoveries, numbers of embryos plus ova recovered were affected by age of donor, dose of FSH and the interaction of the two (P<.05). Among older donors, increasing doses of FSH were associated with an increase in the number of ova plus embryos recovered. However, among younger donors, increasing doses of FSH had a negative effect. Numbers of embryos, rates of fertilization and numbers of transferable embryos decreased (P<.05) with advancing age and increased (P<.05) with increasing doses of FSH. Greater numbers of ova plus embryos were recovered when treatment with FSH was begun on d 10 or 11 as compared with d 7, 8, 9, 12, 13 or 14 (P<.001). It was concluded that an increase in age of donor had a negative influence on the success of superovulation and the production of transferable embryos, and that the response to FSH was affected by age of donor.

¹ Supported by a grant from Select Sires, Inc., and by Hatch Project 224. Published with the approval of the Director of the West Virginia Agr. and For. Exp. Sta. as Scientific Paper No. 1961.

² Dept. of Obstet. and Gynecol.

³ Dept. of Statist. and Computer Sci.

⁴ Director of Research, Select Embryos, Inc.

⁵ General Manager, Select Embryos, Inc.

⁶ Div. of Anim. and Vet. Sci.

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