J. Anim Sci.
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J. Anim Sci. 1986. 62:1693-1702.
© 1986 American Society of Animal Science
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Inositol and Hepatic Lipidosis. II. Effect of Inositol Supplementation and Time from Parturition on Serum Insulin, Thyroxine and Triiodothyronine and Their Relationship to Serum and Liver Lipids in Dairy Cows1

B. J. Gerloff2,3,, T. H. Herdt4, W. W. Wells5, R. F. Nachreiner4 and R. S. Emery2,6,

Michigan State University, East Lansing 48824

Abstract

Percutaneous liver biopsies and blood samples were obtained from 80 dairy cows in nine Michigan herds over the peripartum period. Thirty-nine cows were fed 17 g of supplemental inositol and 41 were fed a placebo. Liver biopsies were assayed for total myoinositol and triglyceride (TG) concentrations. Blood samples were assayed for serum dextran precipitable cholesterol, nonesterified fatty acids (NEFA), insulin, thyroxine (T4), free T4 (FT4), triiodothyronine (T3) and free T3 (FT3) concentrations. Serum concentrations of insulin and the thyroid hormones decreased near parturition, with lowest concentrations occurring in the immediate postpartum period. Concentrations of T3 correlated well with T4, and the concentrations of free thyroid hormones reflected concentrations of total thyroid hormones. The percentage of hormone in the free fraction remained constant over time. Serum insulin, T3 and T4 were negatively correlated with serum NEFA and liver TG concentrations. Thyroid hormone concentrations were positively correlated with serum dextran precipitable cholesterol concentrations. Inositol supplementation was associated with reduced circulating T3 and FT3 concentrations, but not T4 and FT4 concentrations. Changes in hormone concentrations at parturition and their relationship to liver TG and serum NEFA concentrations were consistent with a metabolic adaptation by the dairy cow to the negative energy balance of early lactation.

Footnotes

1 Published with the approval of the Director of the Agr. Exp. Sta. as Journal Article No. 11595. The authors thank Emerson Potter, Ed Veenhuizen and Tom Cain of Eli Lilly and Co., Indianapolis, IN for technical assistance.

2 Dept. of Anim. Sci.

3 Present address: Seneca Bovine Services, P.O. Box 436, Marengo, IL 60152.

4 Dept. of Large Anim. Clin. Sci.

5 Dept. of Biochem.

6 To whom reprint requests should be addressed.






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Copyright © 1986 by the American Society of Animal Science.