J. Anim Sci.
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J. Anim Sci. 1986. 62:1682-1692.
© 1986 American Society of Animal Science
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Inositol and Hepatic Lipidosis. I. Effect of Inositol Supplementation and Time from Parturition on Liver and Serum Lipids in Dairy Cattle1

B. J. Gerloff2,3,, T. H. Herdt4, W. W. Wells5, J. S. Liesman2 and R. S. Emery2,6,

Michigan State University, East Lansing 48824

Abstract

Percutaneous liver biopsies and blood samples were obtained from 80 multiparous dairy cows in nine Michigan herds. Biopsies and samples were obtained serially over the peripartum period. Thirty-nine cows received 17 g of supplemental myoinositol in the diet to test its use as a possible lipotropic substance and 41 received a placebo. Liver biopsies were assayed for triglyceride (TG) and total myoinositol content. Serum was assayed for dextran precipitable cholesterol and non-esterified fatty acids (NEFA). Inositol supplementation had no effect on any of the lipid variables. There was a significant herd effect on liver inositol, serum dextran precipitable cholesterol and NEFA concentrations. Serum NEFA and liver TG concentrations increased in the immediate postpartum period, while dextran precipitable cholesterol decreased. A significant herd x period interaction existed for liver TG and serum dextran precipitable cholesterol concentrations. Liver TG and serum NEFA concentrations were positively correlated. Excessive infiltration of bovine liver with lipid at calving appears to be an exaggerated manifestation of normal metabolic changes.

Footnotes

1 Published with the approval of the Director of the Agr. Exp. Sta. as Journal Article No. 11592. The authors thank participating herd owners for providing animals, Pam Walton and Barb Hunderman for technical assistance, and Dr. Clyde Anderson for statistical advice.

2 Dept. of Anim. Sci.

3 Present address: Seneca Bovine Services, P.O. Box 436, Marengo, IL 60152.

4 Dept. of Large Anim. Clin. Sci.

5 Dept. of Biochem.

6 To whom reprint requests should be addressed.






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Copyright © 1986 by the American Society of Animal Science.