J. Anim Sci.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J. Anim Sci. 1986. 62:1308-1316.
© 1986 American Society of Animal Science
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Galitzer, S. J.
Right arrow Articles by Dayton, A. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Galitzer, S. J.
Right arrow Articles by Dayton, A. D.

Lasalocid Toxicity in Cattle: Acute Clinicopathological Changes1,2,

S. J. Galitzer, F. W. Oehme, E. E. Bartley3 and A. D. Dayton4

Kansas State University, Manhattan 66506

Abstract

Thirty-six steers (148 to 500 kg) divided into six equal groups were used in a toxic syndrome study of lasalocid and monensin given as a single oral dose. One group was given a placebo, a second group received monensin (25 mg/kg body weight) and the other four groups received lasalocid at 1, 10, 50 or 100 mg/kg body weight (bw). No toxic signs developed in cattle given placebo or lasalocid at 1 or 10 mg/kg bw dose. The earliest toxic signs were muscle tremors, tachycardia and rumen atony. After 24 h, the cattle were dehydrated, anorectic and had diarrhea. Deaths occurred between d 1 and 22.5 in the groups receiving lasalocid at 50 and 100 mg/kg bw and monensin. Altered values in blood leucocytes, erythrocytes, hemoglobin, hematocrit, total protein, albumin, creatinine, urea nitrogen, total bilirubin, creatine kinase, lactic dehydrogenase, calcium, chloride and inorganic phosphate occurred 1 d after dosing; urine pH and specific gravity also changed 1 d after dosing. Maximum changes occurred at d 3. Most of the changes were indicative of dehydration rather than specific organ damage.

Footnotes

1 Contribution No. 84-518-J, Dept. of Anim. Sci. & Industry, Surgery & Medicine and Statistics, Kansas Agr. Exp. Sta. This research was supported in part by a grant from Hoffmann-LaRoche, Inc., Nutley, NJ.

2 The authors are grateful to Mr. Lloyd Manthe for his invaluable assistance.

3 This study was one of the last projects Dr. Bartley completed before his death.

4 Present address: Pfizer, Inc., Anim. Health Res., P.O. Box 88, Terre Haute, IN 47808.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1986 by the American Society of Animal Science.