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Changes in the Concentration of Hypothalamic and Hypophyseal Receptors for Estradiol in Pregnant and Postpartum Ewes¹

Colorado State University⁴, Fort Collins 80523

Abstract

The sensitivity of the hypothalamic-pituitary axis to estradiol was evaluated by monitoring changes in the concentration of receptors for estradiol during gestation and the postpartum period of the ewe. Ewes that had been bred during anestrus so that lambing would occur during the breeding season were killed on d 50 and 140 of gestation or on d 2, 13, 22 and 35 postpartum. Total cytosolic receptors for estradiol were quantified in the anterior and posterior hypothalamus, median eminence, anterior pituitary and cerebral cortex. Concentration and total number of receptors for estradiol in the anterior and posterior hypothalamus and anterior pituitary gland during gestation through d 13 postpartum were similar but increased (P<.05) by d 22 and 35 postpartum. Changes in the concentration of receptors for estradiol were tissue-specific because stage of reproduction did not influence the number of receptors for estradiol in the median eminence or cerebral cortex. Increases in the concentration of receptors for estradiol in hypothalamic and pituitary tissues on d 22 postpartum immediately preceded the onset of normal ovarian cyclicity in ewes. From these data we conclude that resumption of reproductive cycles in postpartum ewes occurs about the time concentrations of receptors for estradiol in the anterior pituitary gland and hypothalamus increase.

¹ Supported by NIH grants HD07841, HD13568 and the Colorado State Univ. Exp. Sta.

² Supported by NIH training grant HD07031. Present address: Dept. of Anim. Sci., Univ. of Arizona, Tucson.

³ Present address: Dept. of Biol. Sci., Kent State Univ., Kent, OH.

⁴ Dept. of Physiol, and Biophys.

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