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Effect of Streptozotocin-Induced Diabetes in Primiparous Swine on Subsequent Reproductive Performance^1,2,

Virginia State University^,4, Petersburg 23803

Abstract

A follow-up study was conducted to determine the effects of streptozotocin-diabetes during the first parity on subsequent reproductive performance of sows. Only in the first parity, two doses of streptozotocin (50 and 100 mg/kg body weight) were administered to two groups of pregnant gilts at 80 d of gestation; a third group of gilts served as a control. Second-parity reproductive performance showed that gestation length, placental weight, mean birth weight of the litter, litter size and number of pigs born alive were not affected (P>.05) by maternal diabetes. Maternal serum glucose and fructose were greater (P<.01) in high-dose sows than in the low-dose and the control dams. Serum free fatty acids (FFA) were higher (P<.05) in high-dose dams than in control dams at d-1 and d 112 of gestation; no differences were observed between the high-dose and the low-dose during the same period. Liver and kidney weight, as well as DNA and RNA content, were greater (P<.01) in pigs from high-dose dams than in those of the other treatments. Liver protein was elevated (P<.01) in the progeny of high-dose dams. Dry matter and percent lipid were higher (P<.05 and P<.01, respectively), in pigs from high-dose sows than those from other treatment. Serum glucose, fructose and FFA of piglets were not affected by previous treatment of the dam. The results showed that streptozotocin at high doses (100 mg/kg body weight) induced overt diabetes without impairment of subsequent parity, while at low doses, diabetes appeared to be transient, demonstrating that the diabetogenic effect of streptozotocin is dose-related and may be compatible with reproductive performance in pigs.

¹ Contribution of Virginia State Univ. and Journal Article No. 143.

² The author expresses his appreciation to Mr. F. Ogolla for his assistance with blood and tissue analysis.

³ Agr. Res. Sta.

⁴ The use of any trade names or vendors does not imply approval to the exclusion of the other products or vendors that may also be suitable.