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Vanadium Metabolism in Sheep. III. Influence of Dietary Vanadium on Kinetics of ⁴⁸V Administered Orally or Intravenously and Comparison of Compartmental and Graphical Models^1,2,

University of Florida, Gainesville 32611

Abstract

Radiotracer techniques were used to investigate the influence of dietary stable V on the excretion, distribution and blood clearance kinetics of ⁴⁸V in 14 rams averaging 58 kg body weight. Rams were fed a basal diet with added levels of 0, 50 or 200 mg/kg V as NH₄VO₃ for 25 wk before either oral or iv administration of the isotope. A three-compartment model was determined by graphical logarithmic analysis of blood disappearance data from iv-dosed rams and compared with a simultaneous multicompartment model, which made it possible to ascribe physiological processes to the components of the graphical model. The principal route of excretion of ⁴⁸V administered iv was via urine, whereas the isotope given orally was excreted almost entirely by way of feces, resulting in low tissue and urinary ⁴⁸V levels. Increasing dietary V increased (P<.05) the percentage of dose excreted in urine regardless of dosing route, but dietary V had no effect on ⁴⁸V excreted in feces. Stable dietary V had no effect on blood clearance rates of orally or iv-dosed rams. Dietary V addition decreased ⁴⁸V concentration in kidney (P<.01), liver, spleen, testes and muscle (P<.05) of iv-dosed rams, but had no effect in rams dosed orally. Kidney, bone, liver and spleen retained the highest levels of ⁴⁸V activity 144 h after dosing. Dietary V appeared to have a minimal effect on V kinetics in rams.

¹ Florida Agr. Exp. Sta. Journal Ser. No. 6263.

² The authors acknowledge American Cyanamid Co., Princeton, NJ; Int. Minerals and Chem. Corp., Mundelein, IL; Moorman Manufacturing Co., Quincy, IL; and Occidental Chem. Co., Houston, TX for funds in support of this research; Pfizer, Inc., Terre Haute, IN for supplying vitamins A and D; Monsanto Chem. Co., St. Louis, MO for supplying ethoxyquin and L. A. Zech, Natl. Inst. of Health, Bethesda, MD for assistance with the SAAM model.

³ Present address: Food and Drug Administration (HFV-128), 5600 Fishers Lane, Rockville, MD 20857.

⁴ Dept. of Anim. Sci.

⁵ Dept. of Med., College of Med.