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The Distribution of Orally Administered ¹⁴C-Aniline HCl in Tissues of Dairy Cattle, Swine and Laying Pullets^1,2,

Oak Ridge Associated Universities, Oak Ridge, TN 37831

Abstract

Single or chronic daily (30 d) doses of ¹⁴C-aniline (an aromatic amine) were administered to dairy cattle, swine and laying pullets to determine the amount of an ingested synfuel-related chemical that would remain in consumable animal products. The ¹⁴C-residues were found in muscle, liver, other edible organs and fat, as well as in milk and eggs. The predominant site of deposition in acute- and chronic-exposed pullets was kidney, followed by internal yolk (immature ovum of ovary) and then liver. Egg yolk was the major site of ¹⁴C-radioactivity in whole eggs. Liver, then kidney, were the major sites of deposition in acutely exposed swine; when chronically exposed, only liver showed preferential deposition with other tissues surveyed yielding similar concentration values. Dairy cattle yielded tissue distribution patterns similar to chronic swine. Within 8 h after an acute exposure, ¹⁴C-residue was detected in milk which reached its maximum at 24 to 32 h. Our data demonstrate that derived concentration values of ¹⁴C-residue in tissues was dependent upon the species studied as well as on the mode of exposure, acute versus chronic. Although the concentration values were variable, sufficient amounts of ¹⁴C-aniline and(or) its metabolites were found in consumable products.

¹ Oak Ridge Associated Universities is under contract with the U.S. Department of Energy, Contract No. DE-AC05-760R00033. Although the research described in this article has been funded wholly or in part by the United States Environmental Protection Agency (EPA) through Interagency Agreement No. DW 89930309-01-0 to the Department of Energy, it has not been subjected to EPA review and therefore does not necessarily reflect the views of EPA, and no official endorsement should be inferred.

² The authors thank F. L. Snyder for manuscript preparation.

³ To whom reprint requests should be addressed.