J. Anim Sci.
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J. Anim Sci. 1985. 61:179-186.
© 1985 American Society of Animal Science
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Effect of Diet Particle Size and Feeding of H2-Receptor Antagonists on Gastric Ulcers in Swine1

R. D. Hedde2, T. O. Lindsey, R. C. Parish, H. D. Daniels, E. A. Morgenthien and H. B. Lewis

SmithKline Animal Health Products, West Chester, PA 19380 and SmithKline Beckman Preclinical Research and Development, Upper Merion, PA 19406

Abstract

Four experiments were conducted to evaluate the effect of diet and the administration of H2-antagonists in feed on gastric ulcer formation and performance of growing-finishing swine. Pigs receiving a finely ground diet (< 1mm) grew faster (.73 vs .68 kg/d, P<.01) and had better feed utilization (3.47 vs 3.76, P<.01) than pigs receiving a cracked corn-based diet. Incidence of ulcers in the esophageal region of the stomach of pigs fed the finely ground diet was greater (P<.01) than in pigs fed cracked corn. The average daily gain of pigs receiving the finely ground diet was inversely related to ulcer incidence (r = .403, P<.01, df = 59). The addition of 5, 10, 20 or 100 ppm of the H2-antagonist, metiamide, or 6, 18 or 54 ppm of SK&F 93479 to the finely ground diet did not improve pig performance or affect the incidence of gastric ulceration. The addition of 2, 6 and 18 ppm of SK&F 93479 to a corn-soy diet containing 4.5% alfalfa meal caused a reduction in gastric ulceration (P<.05) and improved feed utilization by 3.2% (P<.05). These data suggest that finely ground diets improve the performance of growing-finishing swine, but increase the incidence of ulcers in the esophageal region of the stomach. Severe gastric ulceration adversely affects swine performance. Feeding H2-antagonists does not reduce the ulcerogenic properties of finely ground diets, suggesting factors other than gastric acid secretion are involved in ulcerogenesis. The use of H2-antagonists in corn-soy diets improves feed utilization and reduces ulceration.

Footnotes

1 The authors express their appreciation to Drs. C. R. Ganellin and M. E. Parsons for their support of this project.

2 Address correspondence to: Dr. R. D. Hedde, SmithKline Animal Health Products, 1600 Paoli Pike, West Chester, PA 19380.

3 Metiamide; l-methyl-3-2- [[(5-methylimidazol-4-yl)methyl] thio] ethyl] -2-thiourea.






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Copyright © 1985 by the American Society of Animal Science.