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- and 24R-Hydroxylase Activities and Plasma 1,25-Dihydroxyvitamin D3 Concentration1,2,US Department of Agriculture3, Ames, IA 50010
Abstract
Results of studies on the effect of dietary P deprivation on pig renal l
- and 24-hydroxylase activities and on concentrations of plasma alkaline phosphatase, Ca, P and vitamin D metabolites are presented. Renal l
-hydroxylase activity was increased six- to eightfold and plasma 1,25-dihydroxyvitamin D3 concentration increased two- to threefold in pigs fed a low P diet (.085% P) compared with pigs fed a control diet (.6% P). In contrast, renal 24-hydroxylase activity and plasma 25-hydroxy-vitamin D concentration did not differ between diet groups. Plasma alkaline phosphatase activity was two to four times higher in pigs fed the low P diet compared with pigs fed the control diet. The rate of gain by pigs fed the low P diet was less than pigs fed the control diet. The low P diet was associated with a prolonged elevation of renal l
-hydroxylase activity in spite of the presence of a pronounced hypercalcemia.
1 The authors gratefully acknowledge the expert statistical analysis assistance of Dr. Jerry Sacks and the expert technical assistance of Mrs. Cynthia Hauber, Ms. Judy Pochop, Ms. Terrie Wierenga and Mr. Don McDorman, Derrel Hoy, Ken Johnson and Jesse Goff.
2 Mention of a trade name, proprietary product, or specific equipment does not constitute a guarantee or warranty by the USDA and does not imply its approval to the exclusion of other products that may be suitable.
3 National Animal Disease Center, ARS, USDA, P.O. Box 70.
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