J. Anim Sci.
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J. Anim Sci. 1985. 60:652-658.
© 1985 American Society of Animal Science
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Effects of In Vitro Ronnel on Metabolic Activity in Subcutaneous Adipose Tissue and Skeletal Muscle from Steers1

Michele L. Trankina2, Donald C. Beitz3 and Allen H. Trenkle4

Iowa State University, Ames 50011

Abstract

Ronnel [0,0-dimethyl 0-(2,4,5-trichlorophenyl) phosphorothioate] is an organophosphate pesticide with growth-promoting properties. Experiments were conducted to determine effects of ronnel on oxidation of and fatty acid synthesis from acetate and glucose as indices of metabolic activity in subcutaneous adipose tissue and skeletal muscle from 6-, 12- and 18-mo-old steers. Ronnel depressed metabolic activity in adipose tissue from 6- and 12-mo-old steers without concomitantly decreasing metabolic activity in skeletal muscle. Production of CO2 and fatty acids from acetate and glucose in tissues from 18-mo-old steers was influenced less by ronnel than in tissues from younger steers. Interactions of ronnel with thyroxine or growth hormone on acetate oxidation and conversion to fatty acids in adipose tissue also were investigated. Thyroxine increased acetate oxidation and decreased fatty acid synthesis. Ronnel interfered with the metabolic effects of thyroxine. Growth hormone, with or without ronnel, did not affect metabolic activity of adipose tissue. Ronnel seemingly alters the partitioning of acetate and glucose between major metabolic processes in adipose tissue and skeletal muscle.

Footnotes

1 Journal Paper No. J-11222 of the Iowa Agr. and Home Econ Exp. Sta. Ames. Project No. 2507. This research was supported partly by Dow Chemical, Midland, MI 48640. Ronnel also was supplied by Dow. Some of the data were reported at the 1982 annual meeting of the Amer. Inst, of Nutr. (Fed. Proc. 41:343). The authors acknowledge the assistance of Daniel Bucknam in performing experimental analyses.

2 Present address: Dept. of Biochem., The Univ. of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284.

3 Depts. of Anim. Sci. and Biochem-Biophys. To whom reprint requests should be addressed

4 Dept. of Anim. Sci






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Copyright © 1985 by the American Society of Animal Science.