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Inhibition of Bovine Luteal Function by Indomethacin^1,2,3,

New York State College of Veterinary Medicine⁵, Cornell University, Ithaca, NY 14853

Abstract

Experiments were conducted to determine the effects of infusing indomethacin, a prostaglandin synthetase inhibitor, into the uterine lumen on the development and function of the bovine corpus luteum in the presence and absence of concurrently administered oxytocin. Each treatment was given twice daily on d 4, 5 and 6 of the estrous cycle. Treatments (six heifers/group) and resulting estrous cycle lengths were as follows: (1) untreated controls, 20.6 ± .4 d; (2) .2 M phosphate buffer vehicle infused into the uterine lumen, 21.0 ± .6 d; (3) 40 mg indomethacin infused into the body of the uterus, 16.5 ± 1.0 d; (4) 150 USP units oxytocin injected sc, 10.0 ± 1.2 d and (5) a combination of oxytocin and indomethacin as in treatments 3 and 4, 14.1 ± 1.3 d. Plasma concentrations of progesterone were lower (P<.05) in each treatment group from d 7 onward, when compared with untreated and vehicle-treated controls. Indomethacin alone effectively inhibited the development and function of the corpus luteum, and was without effect on oxytocin-induced inhibition of luteal function. In summary, it appears that a prostaglandin of either uterine or ovarian origin, or both, is required for the normal development and function of the bovine corpus luteum.

¹ This research was supported in part by NIH grant HD06718-12.

² authors thank D. G. Bianchi, S. L. Bushmich and D. L. King for skillful technical assistance.

³ Presented in part at the 74th Annu. Meet. of The Amer. Soc. of Anim. Sci., August 8-11, 1982, Univ. of Guelph, Ontario, Canada.

⁴ To whom reprint requests should be directed.

⁵ Dept. of Physiology.

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