J. Anim Sci.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J. Anim Sci. 1985. 60:511-518.
© 1985 American Society of Animal Science
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tobioka, H.
Right arrow Articles by Kawashima, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tobioka, H.
Right arrow Articles by Kawashima, R.

Hexestrol Residues and Metabolites in the Tissues of Wethers Injected with Hexestrol Dicaprylate or Hexestrol

Hisaya Tobioka1,2, and Ryoji Kawashima4

Kyoto University, College of Agriculture,4, Kyoto 606, Japan

Abstract

Four young (23 kg body weight) and two mature wethers (52 and 92 kg body weight) were subcutaneously injected with hexestrol (HX) or HX dicaprylate (HX-D) and killed 41 d later. The HX residues, comprising free, glucuronide and KOH hydrolyzable forms plus metabolites were determined by gas chromatography after liquid-liquid extraction and silica gel chromatographic purification of tissue sample. The HX residues were observed to be at concentrations of .1 to 1.0 ppb in most of the tissues examined. Maturity of the animals and the two hormonal formulations resulted in little difference in residues. The KOH hydrolyzable fraction was hardly detected in the tissues examined. Free HX was a major residue in muscle, representing about 70% of HX residues. Glucuronide HX represented 70 to 80% of HX residues in liver and kidney. In lung, glucuronide and free HX were present in similar amounts. This study showed that the gross metabolic patterns of HX and its esters are similar to other estrogens and steroids.

Footnotes

1 To whom correspondence should be addressed.

2 Present address: Kyushu Tokai Univ., Faculty of Agriculture, Choyo-son, Aso-gun, Kumamoto 869-14, Japan.

3 The authors express appreciation to Mr. H. Araki, Mr. Y. Saba and Mr. I. Fujiwara for their help in conducting the animal experiment.

4 Dept. of Anim. Sci.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1985 by the American Society of Animal Science.