J. Anim Sci.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J. Anim Sci. 1985. 60:248-257.
© 1985 American Society of Animal Science
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Garst, J. E.
Right arrow Articles by Szabo, R. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Garst, J. E.
Right arrow Articles by Szabo, R. R.

Species Susceptibility to the Pulmonary Toxicity of 3-Furyl Isoamyl Ketone (Perilla Ketone): in Vivo Support for Involvement of the Lung Monooxygenase System1

J. E. Garst2, W. C. Wilson2, N. C. Kristensen2, P. C. Harrison2, J. E. Corbin2, J. Simon3, R. M. Philpot4 and R. R. Szabo5

University of Illinois, Urbana 61801

Abstract

To explore a possible relationship between metabolism and lethality, the acute toxicity of naturally occurring perilla ketone (PK), 1-(3-furyl)-4-methyl-pentan-1-one, was examined in the uninduced mouse, hamster, rabbit, dog and pig. The LD50 (± SE), determined using intraperitoneal (ip) injection, for the mouse and hamster were low at 5.0 ± .3 and 13.7 ± .9 mg/kg, respectively. The rabbit died from an ip dosage of near 14 mg/kg and estimated ip LD50 dosages were quite high for the dog and pig, being 106 ± 25 mg/kg and over 158 mg/kg, respectively. Dogs and the pig that died from ip injections of PK displayed varying degrees of midzonal and centrilobular liver damage and dogs also had elevated serum alkaline phosphatase and glutamic-pyruvic transaminase activities. In contrast, rodents and rabbits display only pulmonary toxicity from this agent. Cytochromes P-450 and bs concentrations and NADPH-cytochrome c reductase activity were determined for the lung, liver and kidney of mice, hamsters, rabbits, dogs, swine, sheep and cattle. High correlation between lethality and enzyme concentration further supports the hypothesis that enzymatic bioactivation of PK is required for toxicity in all species.

Footnotes

1 This study was assisted by the Univ. of Illinois Research Board, the Biomedical support group (BRSG-2O7-RRO7038O) and the U.S. Government (Hatch 20-323 and NIEHS 02193).

2 Dept. of Anim. Sci.

3 Dept. of Vet. Pathobiol.

4 National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.

5 Dept. of Vet. Med., Basic Sci.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1985 by the American Society of Animal Science.