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Efficacy of Nosiheptide as a Growth Promotant for Growing-Finishing Swine-A Cooperative Study^{1, 2, 3, 4,}

University of Kentucky, Lexington 40546 , Iowa State University, Ames 50011 and Animal Technautics, Terre Haute, IN 47802

Abstract

A cooperative study involving 296 pigs was conducted at two experiment stations and at a commercial research farm to evaluate the efficacy of nosiheptide as a growth promotant for growing-finishing swine. At each station, five or six replicate pens of four or five pigs/pen were fed a fortified, corn-soybean meal basal diet with 0, 5.5, 11 or 22 ppm nosiheptide. Initial and final weights averaged 11 and 92 kg, respectively. Daily gain increased quadratically (623, 664, 669, 678 g/d; P<.03) and feed/gain decreased quadratically (3.35, 3.24, 3.24, 3.28; P<.02) with increasing level of nosiheptide. Breakpoint analysis indicated that gain plateaued at 6.8 ppm and feed/gain at 5.5 ppm of nosiheptide. Averaged across all levels of nosiheptide, gain and feed/gain during the growing phase (11 to 52 kg body weight) were improved by 13.1 and 7.6%, respectively, by feeding the antibiotic. For the entire growing-finishing period, gain was improved by 5.3% and feed/gain by 2.9% in pigs fed nosiheptide. Although there were large differences in gain and feed/gain, the responses to dietary treatments were similar among the three stations. The results indicate that nosiheptide is an effective growth-promoting agent for growing-finishing swine.

¹ Journal Paper No. 83-5-84 of the Kentucky Agr. Exp. Sta., Dept. of Anim. Sci.

² Journal Paper No. J-11062 of the Iowa Agr. and Home Econ. Exp. Sta., Ames. Project No. 2394.

³ This study was supported in part by a grant-in-aid from Rhodia Inc., Hess and Clark Div., Ashland, OH 44805 (presently Rhone-Poulenc, Inc., New Brunswick, NJ 08901).

⁴ Nosiheptide is an Investigational New Animal Drug that is not currently cleared by the Food and Drug Administration for use in swine.