J. Anim Sci.
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J. Anim Sci. 1984. 59:974-980.
© 1984 American Society of Animal Science
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Effects of Maternal Streptozonocin-Diabetes on Fetal Growth, Energy Reserves and Body Composition of Newborn Pigs1,2,

M. O. Ezekwe3,4,, E. I. Ezekwe,1, D. K. Sen5 and F. Ogolla4

Virginia State University, Petersburg 23803

Abstract

Two doses of Streptozotocin (50 and 100 mg/kg body weight) were administered to two groups of pregnant gilts at d 80 of gestation to determine the influence of two levels of maternal diabetes on the gilts, their developing progenies and the body composition of the pigs. All the experimental animals received 1.82 kg of gestation diet/day throughout gestation. Serum glucose concentration increased to hyperglycemic levels in lowdose and high-dose groups; insulin concentrations decreased (P<.01) in the high-dose, but not in the low-dose group (P>.05). Maternal free fatty acids (FFA) increased (P<.05) in both treatment groups when compared with the control. However, birth weight of the litter and litter size were not affected. The liver weight increased (P<.01) in the progeny of high-dose but not the low-dose group. Total liver DNA and RNA were not altered by the treatments, however; total liver protein and protein:DNA ratio increased (P>.01) in the progeny of high-dose gilts. Pigs from high-dose and low-dose groups showed increases (P<.01) in liver glycogen concentrations and percentage liver lipid. Body chemical composition data showed increases in percentage dry matter and percentage lipid (P<.05 and P<.01, respectively) in the progeny of high-dose but not in the low-dose group. It was concluded that strepto- zotocin administered to gestating gilts increased the maternal nutrient supply to the developing pigs, which resulted in higher nergy status of the pigs at birth.

Footnotes

1 Contribution of Virginia State Univ. and Journal Article No. 131. This investigation was supported by CSRS Project No. VA X521135.

2 The authors wish to express their thanks to S. M. Holmes for her assistance with tissue and blood analyses and to S. Braye for typing the manuscript.

3 Reprint request should be addressed to Dr. M. O. Ezekwe, P.O. Box 456, Virginia State Univ., Peters burg, VA 23803.

4 Dept. of Anim. Sci. and Prevet. Med.

5 Dept. of Life Sci.






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Copyright © 1984 by the American Society of Animal Science.