HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Rothschild, M. F. Articles by Warner, C. M. Search for Related Content PubMed PubMed Citation Articles by Rothschild, M. F. Articles by Warner, C. M.

Breed and Swine Lymphocyte Antigen Haplotype Differences in Agglutination Titers Following Vaccination with B. Bronchiseptica^1,2,

Iowa State University, Ames 50011

Abstract

Genetic differences in immune response to B. bronchiseptica after vaccination with a commercial B. bronchiseptica bacterin were investigated in 1,069 8-wk-old pigs. These pigs were from 65 litters born in the spring and 66 litters born in the fall of 1982 and were purebreds from the Chester White (n = 128), Duroc (n = 281), Hampshire (n = 143), Landrace (n = 309) and Yorkshire (n = 208) breeds. Each litter was raised separately. Individual pigs were vaccinated im at 4 and 6 wk of age with 2 ml of B. bronchiseptica bacterin. At 8 wk of age, 8 ml of blood were collected from each animal and serum prepared to determine agglutinating antibody titers against B. bronchiseptica bacterin by a bacterial agglutination method. In addition, lymphocytes were separated from 1 ml of heparinized blood and used to determine Swine Lymphocyte Antigen (SLA) haplotypes by using cytotoxic antibodies against the SLA complex. Antisera for 3 SLA haplotypes were made available by the National Institutes of Health. Results indicated that breed of pig (P<.01) and dam of pig (P<.01) affected the immune response of the pig after B. bronchiseptica vaccination. Higher immune response was also associated (P<.05) with one of the SLA haplotypes tested. Heritability estimates for immune response following vaccination were .10 ± .12 (half-sib) and .42 ± .19 (full-sib). Results suggest that the relationship of the SLA complex to immune response in the pig and nonadditive genetic and maternal effects on immune response should be further investigated.

¹ Journal Paper No. J-11260 of the Iowa Agr. and Home Econ. Exp. Sta., Ames, Project No. 2594.

² The authors gratefully acknowledge Dr. Joan Lunney, National Institutes of Health, for supplying antisera, Mr. David Meeker for obtaining blood samples, Norden Laboratories, Lincoln, NE, for supplying vaccine and the National Pork Producers Council and the USDA for partially funding this research.

³ Dept. of Anim. Sci.

⁴ Immunobiology Program.

⁵ Dept. of Biochem. and Biophys.