J. Anim Sci.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J. Anim Sci. 1984. 59:177-181.
© 1984 American Society of Animal Science
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Troxel, T. R.
Right arrow Articles by Kesler, D. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Troxel, T. R.
Right arrow Articles by Kesler, D. J.

Ability of Indomethacin to Alter Prostaglandin Metabolite Concentrations and to Enhance the Function of Corpora Lutea Induced in Postpartum Suckled Beef Cows1,2,3,

T. R. Troxel and D. J. Kesler

University of Illinois4, Urbana 61801

Abstract

Fourteen anovulatory postpartum (38.0 ± 1.9 d) beef cows that ovulated after an injection of 250 µg gonadotropin releasing hormone (GnRH) in saline were used to examine the influence of indomethacin on luteal function. Beginning the d after GnRH, 6 cows were given intrauterine infusions of indomethacin for 14 d and the other eight cows received vehicle. After GnRH treatment, concentrations of progesterone in serum were elevated longer (P<.01) for indometacin treated cows than for vehicle-treated cows. At the same time prosta glandin metabolite (PGFM) concentrations were lower (P<.01) in indomethacin treated cows than in vehicle treated cows. In summary, indomethacin suppressed PGFM concentrations and enhanced function of corpora lutea induced in postpartum suckled beef cows.

Footnotes

1 The prostaglandin metabolite assay and the validation of this assay were conducted under the supervision of Drs. J. E. Hixon and P. G. Weston in their laboratory. The authors appreciate their generosity.

2 Gonadotropin releasing hormone was generously supplied by Dr. M. Brown (CEVA Laboratories). The crystalline 13, 14-dihydro-15-keto-prostaglandin F2{alpha} and the 13, 14-dihydro-15-keto-prostaglandin F2{alpha} antisera were generously supplied by Dr. K. T. Kirton (The Upjohn Co.). The progesterone antiserum wasgenerously supplied by Dr. O. D. Sherwood (Univ. of Illinois).

3 This research was conducted as part of regional research project, NC-113 "Methods for Improvement of Fertility of Cows Postpartum."

4 Dept. of Anim. Sci.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1984 by the American Society of Animal Science.