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Inhibitory Effect of the Bovine Conceptus on Lymphocyte Stimulation¹

University of Wisconsin, Madison 53706

Abstract

Experiments were conducted to determine whether the preimplantation bovine conceptus produces an immunosuppressant as measured by the inhibition of lectin-induced incorporation of thymidine into lymphocytes. The results of the experiments clearly indicated that media from cultured 18-d-old embryos inhibited lectin-induced incorporation of thymidine into bovine lymphocytes. The inhibitory substance was not produced by heat-killed cells from the conceptus, was not toxic to lymphocytes, was not lectin-specific, but did act in a partially reversible manner. The inhibitor had no apparent effect on porcine lymphocytes, a moderate effect on ovine lymphocytes and a potent effect on bovine lymphocytes. The substance appeared to have a molecular weight of between 500 and 10,000 and was ether insoluble and heat stable. The possible chemical nature of the inhibitor and its potential effect on survival of the preimplantation conceptus are discussed.

¹ Research supported by the College of Agricultural and Life Sciences, Univ. of Wisconsin, Madison; Grant No. 5 T32 HD 0700703 from National Institutes of Child Health and Human Development, DHEW and by Grant No. 630-0505 B,C from the Ford Foundation. This is Paper No. 777 from the Dept. of Meat and Anim. Sci.