J. Anim Sci.
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J. Anim Sci. 1983. 57:74-81.
© 1983 American Society of Animal Science
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Effect of Age and Glucocorticoid Administration on the Proteolytic Activity of Gastric Mucosa: a Comparative Study in the Young Rat, Calf and Piglet1,2,3,

G. Pelletier, J. Lanoë, M. Filion and J. Dunnigan

Agriculture Canada, Lennoxville Research Station, Lennoxville, J1M 1Z34 and and Gastrointestinal Reasearch Unit, Sherbrooke University, J1K 2R1, Québec, Canada

Abstract

The proteolytic activity of gastric mucosa markedly increased from 2 to 4 wk of age in rats and from birth to 8 wk in pigs. In calves it was at adult level at birth, then decreased until d 14 and remained at a relatively low level up to d 56 of age. Early postnatal glucocorticoid injections increased (P<.05) the proteolytic activity of gastric mucosa in rats, decreased (P<.05) the abomasal proteolytic activity in calves and had no significant effect in pigs. The high levels of proteolytic activity observed in the rat at earlier ages after glucocorticoid treatment suggested a precocious maturation of the gastric mucosa. Injections of different doses of hydrocortisone acetate and dexamethasone to calves and rats indicated that proteolytic activity of gastric mucosa is only sensitive to high doses (i.e., nonphysioiogicai) of glucocorticoids. The response of gastric mucosa to glucocorticoid injections depended on the animal's age; maximum response was obtained in the early postnatal period while minimal response was observed after weaning.

Footnotes

1 This research was partially supported by Grant No A1963 from the Natural Science and Engineering Research Council of Canada.

2 Representing part of a thesis submitted by the senior author in partial fulfillment of the requirements for a Ph.D. degree.

3 The authors express appreciation to Dr. Michel Morin for undertaking the histological observations.

4 Contribution no. 126.






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