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Comparison of Gleptoferron with Iron Dextran for Anemia Prevention in Young Pigs^1,2,

Kansas State University, Manhattan 66506

Abstract

Gleptoferron, a sterile aqueous colloidal solution of beta-ferric oxyhydroxide and dextran glucoheptonic acid, was compared with iron dextran for the prevention of Fe deficiency anemia in young pigs. Using 26 litters, pigs (within each litter) were randomly allotted to one of three treatments: 1) control (no Fe), 2) iron dextran (200 mg) and 3) gleptoferron (200 mg). Blood was collected at 0, 10, 21 and 50 d post-treatment for red blood cell count (RBC), hematocrit (HCT), hemoglobin (HGB) concentration, serum Fe concentration (Fe) and serum Fe-binding capacity (IBC). At 21 d, 30 pigs (one pig/treatment from each of 10 litters) were killed to determine milligrams nonheme Fe (NHFe) in liver and spleen, bile IBC and concentrations of bile and fecal Fe. There were no differences (P>.05) between Fe sources in 3- or 8-wk body weight or in any of the blood or tissue characteristics. In contrast, control pigs gained less (P<.05) weight and had lower (P<.05) RBC, HGB, HCT, serum Fe and liver and spleen NHFe than those that received iron dextran or gleptoferron. Serum IBC was greater (P<.05) for the control than for Fe-treated pigs. These results demonstrate that the iron from iron dextran and gleptoferron is used with similar efficiency for anemia prevention in young pigs.

¹ Contribution No. 82-363-j, Dept. of Anim. Sci. and Ind. and Vet. Pathol., Kansas Agr. Exp. Sta., Manhattan. The authors wish to acknowledge Susan Pope, Kathy Hood, Cathy Bandyk, Cheryl Hoffman, Kateri Moore and Donna Boyington for their assistance in blood collection and blood analyses.

² Financial support for authors' research has come partially from Continental Animal Health, Division of Burns-Biotec., Omaha, NE.

³ Dept. of Anim. Sci. and Ind.

⁴ College of Vet. Med.

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