| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Kansas State University, Manhattan 66506
Abstract
An experiment involving 118 pigs was conducted to evaluate the influence of weaning pigs at four different ages on in vivo and in vitro cell-mediated immunity. One-half of each litter was weaned at 2, 3, 4 or 5 wk of age; the other one-half remained with the sow as non-weaned controls. Phytohemagglutinin skin-test responses were determined on all pigs. Blastogenic responses of mitogen-stimulated lymphocyte cultures were determined before and after weaning. The intradermal response to phytohemagglutinin was reduced (P<.001) in pigs weaned when 2 or 3 wk old and was suppressed (P<.05) in those weaned when 4 wk old. In vivo cellular immunity was not altered by weaning in 5-wk-old pigs. The capability of lymphocytes to undergo blastogenesis in response to phytohemagglutinin was decreased in pigs weaned at 2 and 3 wk of age (P<.001 and P<.01, respectively). Pokeweed mitogen-stimulated blastogenesis was lower (P<.01) in pigs weaned at 2 wk of age. Mitogen-stimulated lymphocyte blastogenesis was similar (P<.10) in control pigs and those weaned when 5 wk old. These data suggested that weaning pigs when younger than 5 wk old causes physiological changes detrimental to cellular immune reactivity. Those changes could alter disease susceptibility in young pigs.
1 Contribution 82-335-J, Kansas Agr. Exp. Sta.
2 Partially supported by a grant from the National Pork Producers Council, Des Moines, IA 50312.
3 Dept. of Anatomy and Physiol., College of Veterinary Medicine.
4 Dept. of Anim. Sci. and Ind., College of Agriculture.
5 We thank Danielle H. Topliff and Kathy Hood for their excellent technical assistance.
This article has been cited by other articles:
|
|
 |
|
  J. L. Salak-Johnson and J. J. McGlone Making sense of apparently conflicting data: Stress and immunity in swine and cattle J Anim Sci, March 1, 2007; 85(13_suppl): E81 - E88. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Niekamp, M. A. Sutherland, G. E. Dahl, and J. L. Salak-Johnson Immune responses of piglets to weaning stress: Impacts of photoperiod J Anim Sci, January 1, 2007; 85(1): 93 - 100. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. N. Jensen, A. Dalsgaard, A. Stockmarr, E. M. Nielsen, and D. L. Baggesen Survival and Transmission of Salmonella enterica Serovar Typhimurium in an Outdoor Organic Pig Farming Environment. Appl. Envir. Microbiol., March 1, 2006; 72(3): 1833 - 1842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Brown, C. V. Maxwell, G. F. Erf, M. E. Davis, S. Singh, and Z. B. Johnson Ontogeny of T lymphocytes and intestinal morphological characteristics in neonatal pigs at different ages in the postnatal period J Anim Sci, March 1, 2006; 84(3): 567 - 578. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Davis, S. C. Sears, J. K. Apple, C. V. Maxwell, and Z. B. Johnson Effect of weaning age and commingling after the nursery phase of pigs in a wean-to-finish facility on growth, and humoral and behavioral indicators of well-being J Anim Sci, March 1, 2006; 84(3): 743 - 756. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Davis, C. V. Maxwell, D. C. Brown, B. Z. de Rodas, Z. B. Johnson, E. B. Kegley, D. H. Hellwig, and R. A. Dvorak Effect of dietary mannan oligosaccharides and(or) pharmacological additions of copper sulfate on growth performance and immunocompetence of weanling and growing/finishing pigs J Anim Sci, November 1, 2002; 80(11): 2887 - 2894. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
