J. Anim Sci.
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J. Anim Sci. 1982. 55:1417-1424.
© 1982 American Society of Animal Science
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Absorption and Excretion of Pyrrolizidine (Senecio) Alkaloids and their Effects on Mineral Metabolism in Rabbits1

R. A. Swick2,3,, P. R. Cheeke2, N. M. Patton2 and D. R. Buhler4

Oregon State University, Corvallis 97331

Abstract

A metabolism study was conducted with rabbits to determine the effect of consumption of 5% dietary Senecio jacobaea (SJ) on tissue mineral levels and mineral excretion. Gastrointestinal (GIT) absorption of pyrrolizidine alkaloids (PA) from SJ was also studied by monitoring excretion into urine and feces and by the use of ligated gut segments in vitro. Inclusion of SJ into a diet containing added Cu (100 ug/g) and Zn (100 ug/g) caused a 2.6-fold increase in liver Cu concentration (P<.05), decreased total liver Zn (P<.05), and increased plasma Fe (P<.05) when compared with rabbits consuming the same diet without SJ. Fecal and urinary excretion of Cu and Zn were not markedly affected by the addition of Cu, Zn and(or) SJ to rabbit diets. Excretion of PA from SJ in the diet was not affected (P>.05) by the addition of Cu and Zn to the diet. The PA elimination was much greater in urine than feces (P<.001). Isolated PA from SJ were found to be readily transferred across the mucosa of isolated everted sacs of jejunum and ileum in vitro against a concentration gradient. These results suggest that the effects of dietary SJ on alterations in mineral metabolism are not due to changes in GIT mineral elimination. In addition, it appears that the resistance of rabbits to dietary SJ intoxication is not caused by low GIT absorption of PA, but rather by efficient urinary elimination.

Footnotes

1 Technical Paper No. 6167, Oregon Agr. Exp. Sta.

2 Dept. of Anim. Sci. (address reprint requests to P. R. Cheeke).

3 Present address: Monsanto Chemical Co. 800 N. Lindbergh St. Louis, MO 63166.

4 Dept. of Agr. Chem.






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Copyright © 1982 by the American Society of Animal Science.