HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Zimmerman, D. R. Articles by Barnes, H. J. Search for Related Content PubMed Articles by Zimmerman, D. R. Articles by Barnes, H. J.

Effects of Carbadox and Pyrantel Tartrate on Performance and Indices of Mycoplasma Hyopneumoniae and Ascaris Suum Infections in Pig¹

Iowa Agriculture and Home Economics Experiment Station, Ames 50011

Abstract

Effects of carbadox and pyrantel tartrate on rate and efficiency of gain, and on ascariasis and mycoplasmal pneumonia in pigs were investigated in three experiments. Pigs were exposed to a natural infection of Ascaris suum in all experiments and to an experimental infection of Mycoplasma hyopneumoniae in Exp. 1 and 2. Carbadox or pyrantel alone and in combination increased rate of gain and improved feed efficiency in the 28-d period of drug treatments in Exp. 1. However, performance responses did not persist subsequent to the 28-d period of drug treatment. Carbadox improved rate and efficiency of gain in the 63-d period of drug treatment in Exp. 2, but additional responses were not obtained when pyrantel was fed in combination with carbadox. In a third experiment, increases in rate and efficiency of gain of pigs were not obtained when pyrantel was fed in combination with carbadox in the first 28 d, but improved feed efficiency was obtained over the entire 119-d period. In all experiments pyrantel tartrate at 105.6 ppm of diet effectively reduced migrastion of ascarid larvae and establishment of adult ascarids in the intestine. This effectiveness was indicated by blood eosinophil counts, lung and liver lesion scores, fecal egg counts and intestinal ascarid counts. Ascarid migration and establishment of infection in the intestine occurred after removal of pyrantel or its reduction to 26.4 ppm of diet. There was slight indication in Exp. 1 that pneumonic lung involvement was less extensive at 28 d on test in pigs protected from severe ascarid larva migration than in unprotected pigs.

¹ Journal Paper No. J-9318 of the Iowa Agr. and Home Econ. Exp. Sta., Ames. Project No. 2021.

² Dept. of Anim. Sci.

³ Pfizer International, New York 10017.

⁴ Pfizer Central Research, In., Terre Haute, IN 47808.

⁵ Veterinary Medical Research Institute.

⁶ Present address: Pfizer Central Research, Terre Haute, IN 47808