HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Hansard, S. L. Articles by Simpson, C. F. Search for Related Content PubMed PubMed Citation Articles by Hansard, S. L., II Articles by Simpson, C. F.

Vanadium Metabolism in Sheep. I. Comparative and Acute Toxicity of Vanadium Compounds in Sheep^1,2,

University of Florida, Gainesville 32611

Abstract

Twelve Florida native wethers were given ammonium metavanadate, calcium orthovanadate and calcium pyrovanadate by capsule in a study to examine the toxicity of the compounds. The initial daily dosage of 100 mg elemental vanadium was increased by 50 mg at 2-d intervals for an assessment not only of the toxic effects, but also to determine the amount that caused a decline in feed intake to 25% of that of control animals. The initial decline in feed intake was observed at 400 to 500 mg vanadium/d (9.6 to 12 mg/kg body weight, 310 to 3 50 ppm); a rapid decline in feed intake was accompanied by diarrhea. One sheep fed 550 mg vanadium as calcium orthovanadate died 3 d after dosing. One animal on each of the other three treatments was killed and necropsied for immediate comparison. Extensive mucosal hemorrhage of the small intestine and diffuse or petechial subcapsular hemorrhages of the kidneys were observed for sheep fed all compounds. The three vanadium compounds appeared to be similar in toxicity, as determined by abrupt declines in feed intake and pathological changes of the intestine and kidney. For a determination of acute toxicosis, three sheep were given 40 mg/kg body weight of vanadium as NH₄VO₃ in gelatin capsules and two sheep were included as controls. Two of the treated animals died within 80 h after administration and the other three were killds at 96 h. Vanadium content of Kidney, liver, bone, spleen, lung and muscle was elevated by treatment.

¹ Florida Agr. Exp. Sta. Journal Ser. No. 3044.

² The authors wish to acknowledge the National Feed Ingredients Association, des Moines, IA; American Cyanamid Co., Princeton, NJ; International Minerals and Chemical Corp., Mundelein, IL; Ladora Minerals Inc., Victor, IA; Moorman Manufacturing Co., Quincy, IL and Occidental Chemical Co., Houston, TX, fo funds in suppoort of this research, Monsanto Co., St. Louis, MO, for providing Santoquin and Charles Pfizer, Inc., New York, for supplying vitamins A and D.

³ Present address: Food and Drug Administration (HFV-136), 5600 Fishers Lane, Rockville, MD 20857.

⁴ Dept. of Anim. Sci.

⁵ Dept. of Preventive Med.