J. Anim Sci.
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J. Anim Sci. 1982. 55:73-76.
© 1982 American Society of Animal Science
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Fructose Utilization for Nucleic Acid Synthesis in the Fetal Pig1

C. E. White2, E. L. Piper3, P. R. Noland and L. B. Daniels

University of Arkansas, Fayetteville 72701

3 Anim. Sci. Center, Univ. of Arkansas, Fayetteville 72701, for reprint requests.

Abstract

Eight fetal pigs, in utero, were injected ip with 20 µCi/fetus [U14C]—fructose between d 55 and 65 of pregnancy. The isotope was allowed to equilibrate between blood and tissues within injected fetuses for a period of 240 min. Fetal pigs were then sacrificed and nucleic acids were extracted from cold tissue homogenates of skeletal muscle and liver. Nuclide disintegrations per minute recovered in extracted DNA and RNA were used to calculate incorporation of labeled C from fructose. The recovery of labeled C per mmol of nucleic acids from skeletal muscle was greater (P>.05) than that from liver. Relative incorporation of labeled C into skeletal muscle RNA (395.9 pmol/mmol) was greater (P<.05) than for DNA (189.5 pmol/mmol). The same trend was observed for liver RNA (78.0 pmol/mmol) and DNA (55.6 pmol/mmol), but differences were nonsignificant. These data suggest that at least part of the high concentration of endogenous fructose measured in fetal pigs in utero is involved in synthesis of nucleic acids, thereby providing substrate for anabolic functions necessary for fetal growth and development.

Footnotes

1 This paper is published with the approval of the Director of the Arkansas Agr. Exp. Sta.

2 Present address: Univ. of Florida, Institute of Food and Agr. Sci., ARC, Live Oak 32060.






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Copyright © 1982 by the American Society of Animal Science.