J. Anim Sci.
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J. Anim Sci. 1982. 54:763-768.
© 1982 American Society of Animal Science
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Age-Related Changes in the Effects of Serum from Lean and Obese Pigs on Myogenic Cell Proliferation in Vitro1

Ronald E. Allen2, Gail Robinson3, Matthew J. Parsons3, Robert A. Merkel3 and William T. Magee3

Michigan State University, East Lansing 48824 and and University of Arizona, Tucson 85721

Abstract

Two groups of pigs differing in muscle growth and fat deposition potential were studied from birth to 255 d of age. Blood samples were collected at regular intervals and assayed for their ability to promote the proliferation of myogenic cells in vitro. Myogenic cell proliferation activity decreased (P<.01) in a linear fashion with age. Correlations between age and proliferation activity were —.54 and —.48 for lean and obese pigs, respectively. Activity also was greater (P<.05) in lean than in obese pigs. Myogenic cell proliferation activity was highest during the period of growth when satellite cell proliferation in muscle is most active, which suggests that factors circulating in blood could be involved in the regulation of DNA accretion in postnatal muscle. Differences between the two groups of pigs were greatest during the period of growth when in vivo myogenic cell proliferation, i.e., satellite cell proliferation, is most important. The relationship between myogenic cell proliferation activity and the extremely important process of muscle DNA accretion, as well as the possibility that some of the differences in muscle growth potential among animals could be due to circulating levels of these proliferation stimulating agents, warrant further investigation.

Footnotes

1 Michigan Agr. Exp. Sta. Article No. 9890 and Univ. of Arizona Exp. Sta. Article No. 3428. This work was supported by Michigan Agr. Exp. Sta. Projects 1280 and 1182 and grants from the National Pork Producers Council and the USPHS R23 AG01467.

2 Dept. of Anim. Sci., Univ. of Arizona.

3 Dept. of Anim. Sci., Michigan State Univ.






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