J. Anim Sci.
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J. Anim Sci. 1982. 54:89-94.
© 1982 American Society of Animal Science
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Glucose Turnover in Fast-Growing, Lean and in Slow-Growing, Obese Swine1

P. J. Cote2, P. J. Wangsness3, H. Varela-Alvarez3, L. C. Griel, Jr.4 and J. F. Kavanaugh4

Pennsylvania State University, University Park 16802

Abstract

Glucose turnover and associated measurements were compared in genetically obese, slow-growing feral pigs (Ossabaw) and domestic lean, fast-growing (Yorkshire) pigs. Five Ossabaw and five Yorkshire pigs 8 wk of age were prepared with indwelling arterial catheters to facilitate injection of tracer and serial sampling of blood. After a 14-h fast, pigs were administered 100 ;xCi of glucose-6-3H in a single injection; 12 blood samples were obtained over the subsequent 4-h period to obtain tracer dilution curves. Plasma glucose concentrations were the same in both strains (88 mg/100 ml) prior to tracer injection and remained constant for the duration of the 4-h sampling period. Ossabaw pigs exhibited a smaller minimal glucose mass (144 vs 179 mg/kg body weight, P<.01) and space (16 vs 20%, P<.01) when compared with Yorkshire pigs. Glucose replacement rate was greater for Ossabaw pigs than for Yorkshire pigs (3.96 vs 2.97 mg-min-1 *kg_1 body weight, P<.001). Minimal transit time was less in Ossabaw pigs than Yorkshire pigs (36 vs 60 min, P<.001), which reflected the greater rate of irreversible disposal of tracer from the glucose pool of Ossabaw pigs. In conclusion, under these experimental conditions and at similar fasting glucose concentrations, glucose turnover and metabolic clearance rates were greater in Ossabaw than Yorkshire pigs. The results suggest a greater rate of fasting liver gluconeogene-sis during short-term fasting in the young Ossabaw than the Yorkshire pig.

Key Words: Swine • Glucose Turnover • Plasma Glucose • Glucose Clearance

Footnotes

1 Supported in part by NIH Biomedical Sciences Support Grant 5505RR07082-O8 and NIH Grant HD-11121 and authorized for publication as paper no. 5610 in the journal series of the Pennsylvania Agr. Exp. Sta.

2 Present address: Division of Molecular Virology and Immunology, Dept. of Microbiology, Georgetown University sponsored program, 5640 Fishers Lane, Rockville, MD 20852.

3 Dept. of Dairy and Anim. Sci. Send reprint requests to P. J. Wangsness.

4 Dept. of Veterinary Sci






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Copyright © 1982 by the American Society of Animal Science.