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Anthelmintic Activity of Albendazole against Adult Metastrongylus Apri in Artificially Infected Swine^{1 ,2,}

University of Nebraska, Lincoln 68583

Abstract

Three groups of five pigs experimentally infected with lungworm larvae (Metastrongylus apri) were treated with albendazole at 5, 7.5 or 10 mg/kg body weight at 35 days postinfection. The albendazole was administered in the feed. Anthelmintic efficacy, as determined by comparison of postmortem lungworm counts for the treated animals and five infected, untreated1 controls, was 32.6% at 5 mg/kg, 44.3% at 7.5 mg/kg and 60.7% at 10 mg/kg. The 60.7% reduction in lungworms was statistically different at the 5% level of significance. In a second experiment, three groups of five pigs experimentally infected with lungworm larvae (Metastrongylus apri) were treated continuously for 5 days with albendazole in the feed at 10, 20 or 30 ppm, starting at 35 days postinfection. The anthelmintic efficacy, again determined by comparison of postmortem lungworm counts for the treated pigs and five infected, untreated controls, was 99.2% at 10 ppm, 99.9% at 20 ppm and 100% at 30 ppm. These mean reductions from the control values were significant (P<.01).

¹ Published with the approval of the Director, as Paper No. 6138, Journal Ser., Nebraska Agr. Exp. Sta.

² Supported in part by a grant from Smith Kline Animal Health Products, West Chester, PA.

³ Vet. Sci. Dept.