J. Anim Sci.
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J. Anim Sci. 1981. 53:1000-1005.
© 1981 American Society of Animal Science
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Blood Lactate Kinetics in Normal and Stress-Susceptible Pigs1

Peggy S. Darrah, Donald C. Beitz, David G. Topel2 and Lauren L. Christian

Iowa State University3, Ames 50011

Abstract

In vivo rates of lactate metabolism were determined in stress-susceptible (SS) and stress-resistant (SR) pigs. Three SR and three SS pigs were given 20 µCi of [U-14C] L-lactate by a single injection method and resting blood lactate kinetics were measured. Seventeen blood samples were taken during the 60 min after injection. Lactate was separated from the deproteinized plasma by silicic acid column chromatography, and specific radioactivity was determined. Kinetic characteristics were calculated from plots of specific activity versus time. Pigs met steady-state requirements during the sampling period. There were no differences in kinetic characteristics of resting SS and SR pigs. Later, a second isotope injection was given after 5 min of electrical stress. Lactate pool sizes increased similarly in both types of pigs after stress; however, SS pigs had greater plasma lactate concentrations after stress. It is concluded that SS and SR pigs respond differently to stress but have similar capacities to metabolize lactate while resting.

Footnotes

1 Journal Paper No. J-10069 of the Iowa Agr. and Home Econ. Exp. Sta., Ames. Project 2176. Some of the data from this study were presented at the Annu. Meet, of the American Institute of Nutrition, Chicago, IL, April, 1977. Fed. Prod. 36:1173 (Abstr.). This work was supported in part by USDA/CSRS grant 616-15-153. The authors wish to thank Dr. Leland Neuhring and Dr. Craig VanBalen for technical assistance.

2 Present address: Dept. of Anim. and Dairy Sci., Auburn Univ., Auburn, AL 36830.

3 Nutritional Physiology Group, Dept. of Anim. Sci., Iowa State Univ., Ames 50011.






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Copyright © 1981 by the American Society of Animal Science.