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Influence of Intrajugular Administration of Insulin, Glucagon and Propionate on Voluntary Feed Intake of Sheep^{1 ,2,}

The Pennsylvania State University, University Park 16802

⁴ Dept. of Dairy and Anim. Sci. and person to whom reprint requests should be sent.

Abstract

The effect of intrajugular injections of insulin, glucagon and propionate, administered singly and in combination, as possible peripheral feedbacks in the control of feed intake in wethers was studied. A complete mixed diet (25% chopped hay:75% cracked corn) was fed ad libitum. The treatments were saline, 6 mU insulin/kg body weight (BW), 9 ng glucagon/kg BW and 1.3 mg propionate/kg BW. In Exp. 1, five wethers were given the treatments at the beginning of each spontaneous meal over a 24-hr period, and total daily feed intakes were measured. The average number of injections per sheep for a 24-hr period was eight. In Exp. 2, the effects of the treatments on plasma concentrations of insulin, glucagon, propionate and glucose at 15, 30, 60 and 120 min after injection were measured in six other wethers. In Exp. 1, insulin (P<.01), glucagon (P<.01), insulin plus propionate (P<.05) and glucagon plus propionate (P<.05) decreased 24-hr feed intake by 18.5, 15.8, 11.0 and 11.8%, respectively, compared to the saline control. In Exp. 2, plasma insulin concentrations were increased (P<.05) at 15 min after administration of insulin and insulin plus propionate, to 2.0 and 2.1 times the preinjection levels, respectively. Glucagon concentrations in plasma were increased (P<.01) at 15 min after the injection of glucagon, to 2.0 times the pretreatment values. Insulin and glucagon concentrations in plasma were increased only slightly (P<.10) after administration of glucagon plus propionate. No treatments affected glucose or propionate concentrations in the plasma. Increases in plasma concentrations of insulin, glucagon and propionate may interact directly or initiate other mechanisms involved in the short-term control of feed intake by sheep on a concentrate diet.

¹ Authorized for publication as Paper No. 5862 in the Journal Ser. of the Pennsylvania Agr. Exp. Sta.

² Part of the work reported in this paper was presented at the Joint Meet, of the ADSA and ASAS, East Lansing, MI, July 9–13, 1978, and was supported in part by NIH Biomedical Sciences Support Grant 5505RR-07082-08.

³ Present address: Dept. of Anim. Sci., Univ. of Kentucky, Lexington.

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